Literature DB >> 17148038

The role of Rds in outer segment morphogenesis and human retinal disease.

Rafal Farjo1, Muna I Naash.   

Abstract

The Retinal Degeneration Slow (Rds) protein is required by photoreceptors for proper formation of the specialized outer segment organelle. Human mutations in Rds cause a multitude of blinding diseases such as retinitis pigmentosa and macular degeneration. In recent years, the use of animal models and biochemical approaches has provided evidence towards the precise function of Rds and its role in the pathogenesis of human disease. This review addresses the current understanding of the role of Rds in photoreceptor outer segment morphogenesis and provides insight into the design of therapeutic strategies to treat Rds-associated retinal diseases.

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Year:  2006        PMID： 17148038     DOI： 10.1080/13816810600976806

Source DB:  PubMed          Journal:  Ophthalmic Genet        ISSN： 1381-6810            Impact factor:   1.803


  22 in total

Review 1.  Nanoparticles for retinal gene therapy.

Authors:  Shannon M Conley; Muna I Naash
Journal:  Prog Retin Eye Res       Date:  2010-05-07       Impact factor: 21.198

Review 2.  Gene therapy in the Retinal Degeneration Slow model of retinitis pigmentosa.

Authors:  Xue Cai; Shannon M Conley; Muna I Naash
Journal:  Adv Exp Med Biol       Date:  2010       Impact factor: 2.622

3.  Photoreceptor cells with profound structural deficits can support useful vision in mice.

Authors:  Stewart Thompson; Frederick R Blodi; Swan Lee; Chris R Welder; Robert F Mullins; Budd A Tucker; Steven F Stasheff; Edwin M Stone
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-03-25       Impact factor: 4.799

Review 4.  Structural and functional relationships between photoreceptor tetraspanins and other superfamily members.

Authors:  Shannon M Conley; Michael W Stuck; Muna I Naash
Journal:  Cell Mol Life Sci       Date:  2011-06-08       Impact factor: 9.261

5.  Membrane curvature generation by a C-terminal amphipathic helix in peripherin-2/rds, a tetraspanin required for photoreceptor sensory cilium morphogenesis.

Authors:  Nidhi Khattree; Linda M Ritter; Andrew F X Goldberg
Journal:  J Cell Sci       Date:  2013-07-25       Impact factor: 5.285

6.  Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa.

Authors:  Xue Cai; Shannon M Conley; Zack Nash; Steven J Fliesler; Mark J Cooper; Muna I Naash
Journal:  FASEB J       Date:  2009-12-01       Impact factor: 5.191

7.  Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development.

Authors:  Christine Insinna; Lisa M Baye; Adam Amsterdam; Joseph C Besharse; Brian A Link
Journal:  Neural Dev       Date:  2010-04-22       Impact factor: 3.842

8.  Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degeneration.

Authors:  Nikolai P Skiba; William J Spencer; Raquel Y Salinas; Eric C Lieu; J Will Thompson; Vadim Y Arshavsky
Journal:  J Proteome Res       Date:  2013-05-24       Impact factor: 4.466

9.  Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells.

Authors:  Brian M Kevany; Yaroslav Tsybovsky; Iain D G Campuzano; Paul D Schnier; Andreas Engel; Krzysztof Palczewski
Journal:  J Biol Chem       Date:  2013-11-06       Impact factor: 5.157

10.  Effect of Rds abundance on cone outer segment morphogenesis, photoreceptor gene expression, and outer limiting membrane integrity.

Authors:  Rafal Farjo; Steven J Fliesler; Muna I Naash
Journal:  J Comp Neurol       Date:  2007-10-20       Impact factor: 3.215
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