Literature DB >> 17148032

Mesenchymal stromal cells: Tissue repair and immune modulation.

K Le Blanc1.   

Abstract

BM-derived mesenchymal stromal cells (MSC) differentiate along the mesenchymal lineage to bone, fat and cartilage. In vitro, MSC induce little, if any, proliferation of allogeneic lymphocytes. MSC inhibit the proliferation of activated T cells and the formation of cytotoxic T cells. In vivo, they appear to have anti-inflammatory effects. Preliminary studies suggest that MSC preferentially home to damaged tissue and therefore have therapeutic potential. Possible clinical indications include therapy-resistant severe acute GvHD, treatment of rejection of organ allografts and autoimmune disorders.

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Year:  2006        PMID： 17148032     DOI： 10.1080/14653240601045399

Source DB:  PubMed          Journal:  Cytotherapy        ISSN： 1465-3249            Impact factor:   5.414


  71 in total

Review 1.  Mesenchymal stem cells for the sustained in vivo delivery of bioactive factors.

Authors:  Todd Meyerrose; Scott Olson; Suzanne Pontow; Stefanos Kalomoiris; Yunjoon Jung; Geralyn Annett; Gerhard Bauer; Jan A Nolta
Journal:  Adv Drug Deliv Rev       Date:  2010-10-13       Impact factor: 15.470

2.  Prospective identification and skeletal localization of cells capable of multilineage differentiation in vivo.

Authors:  Russell S Taichman; Zhuo Wang; Yusuke Shiozawa; Younghun Jung; Junhui Song; Alex Balduino; Jincheng Wang; Lalit R Patel; Aaron M Havens; Magdalena Kucia; Mariusz Z Ratajczak; Paul H Krebsbach
Journal:  Stem Cells Dev       Date:  2010-10       Impact factor: 3.272

3.  Automated microscopy as a quantitative method to measure differences in adipogenic differentiation in preparations of human mesenchymal stromal cells.

Authors:  Jessica L Lo Surdo; Bryan A Millis; Steven R Bauer
Journal:  Cytotherapy       Date:  2013-08-29       Impact factor: 5.414

Review 4.  Mesenchymal stem and progenitor cells for cartilage repair.

Authors:  Nazish Ahmed; William L Stanford; Rita A Kandel
Journal:  Skeletal Radiol       Date:  2007-10       Impact factor: 2.199

5.  Intramarrow injection of beta-catenin-activated, but not naive mesenchymal stromal cells stimulates self-renewal of hematopoietic stem cells in bone marrow.

Authors:  Ji Yeon Ahn; Gyeongsin Park; Jae Seung Shim; Jong Wook Lee; Il Hoan Oh
Journal:  Exp Mol Med       Date:  2010-02-28       Impact factor: 8.718

6.  Repair of osteochondral defects with biodegradable hydrogel composites encapsulating marrow mesenchymal stem cells in a rabbit model.

Authors:  Xuan Guo; Hansoo Park; Simon Young; James D Kretlow; Jeroen J van den Beucken; L Scott Baggett; Yasuhiko Tabata; F Kurtis Kasper; Antonios G Mikos; John A Jansen
Journal:  Acta Biomater       Date:  2009-08-04       Impact factor: 8.947

7.  microRNAs, Gap Junctional Intercellular Communication and Mesenchymal Stem Cells in Breast Cancer Metastasis.

Authors:  Larissa A Gregory; Rachel A Ricart; Shyam A Patel; Philip K Lim; Pranela Rameshwar
Journal:  Curr Cancer Ther Rev       Date:  2011-08

Review 8.  The therapeutic potential of bone marrow-derived stromal cells.

Authors:  Eva Mezey
Journal:  J Cell Biochem       Date:  2011-10       Impact factor: 4.429

9.  Autologous adipose tissue-derived stem cells for the treatment of complex perianal fistulas not associated with Crohn's disease: a phase II clinical trial for safety and efficacy.

Authors:  S Choi; S-B Ryoo; K J Park; D-S Kim; K-H Song; K H Kim; S S Chung; E J Shin; Y B Cho; S T Oh; W-K Kang; M H Kim
Journal:  Tech Coloproctol       Date:  2017-05-31       Impact factor: 3.781

10.  Transplantation of Human Adipose Mesenchymal Stem Cells in Non-Immunosuppressed GRMD Dogs is a Safe Procedure.

Authors:  M V Pelatti; J P A Gomes; N M S Vieira; E Cangussu; V Landini; T Andrade; M Sartori; L Petrus; Mayana Zatz
Journal:  Stem Cell Rev Rep       Date:  2016-08       Impact factor: 5.739
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