Literature DB >> 17146573

Topical/mucosal delivery of sub-unit vaccines that stimulate the ocular mucosal immune system.

Anthony B Nesburn1, Ilham Bettahi, Xiuli Zhang, Xiaoming Zhu, Winston Chamberlain, Rasha E Afifi, Steven L Wechsler, Lbachir BenMohamed.   

Abstract

Mucosal vaccination is proving to be one of the greatest challenges in modern vaccine development. Although ocular mucosal immunity is highly beneficial for achieving protective immunity, the induction of ocular mucosal immunity against ocular infectious pathogens, particularly herpes simplex virus type 1 (HSV-1), which is the leading cause of infectious corneal blindness, remains difficult. Recent developments in cellular and molecular immunology of the ocular mucosal immune system (OMIS) may help in the design of more effective and optimal immunization strategies against ocular pathogens. In this review, we highlight ocular mucosal immunoprophylactic and immunotherapeutic vaccine strategies that have been evaluated to control the many pathogens that attack the surface of the eye. Next, we describe the current understandings of the OMIS and elucidate the structure and the function of the humoral and cellular immune system that protects the surface of the eye. Results from our recent experiments using topical ocular delivery of peptides-CpG and lipopeptide-based vaccines against HSV-1 infection are presented. The future challenges and issues related to the ocular mucosal delivery of molecularly defined sub-unit vaccines are discussed.

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Year:  2006        PMID： 17146573     DOI： 10.1016/s1542-0124(12)70164-7

Source DB:  PubMed          Journal:  Ocul Surf        ISSN： 1542-0124            Impact factor:   5.033


  25 in total

1.  Therapeutic immunization with a mixture of herpes simplex virus 1 glycoprotein D-derived “asymptomatic” human CD8+ T-cell epitopes decreases spontaneous ocular shedding in latently infected HLA transgenic rabbits: association with low frequency of local PD-1+ TIM-3+ CD8+ exhausted T cells.

Authors:  Arif A Khan; Ruchi Srivastava; Aziz A Chentoufi; Roger Geertsema; Nhi Thi Uyen Thai; Gargi Dasgupta; Nelson Osorio; Mina Kalantari; Anthony B Nesburn; Steven L Wechsler; Lbachir BenMohamed
Journal:  J Virol       Date:  2015-07       Impact factor: 5.103

2.  Immunodominant "asymptomatic" herpes simplex virus 1 and 2 protein antigens identified by probing whole-ORFome microarrays with serum antibodies from seropositive asymptomatic versus symptomatic individuals.

Authors:  Gargi Dasgupta; Aziz A Chentoufi; Mina Kalantari; Payam Falatoonzadeh; Sookhee Chun; Chang Hyun Lim; Philip L Felgner; D Huw Davies; Lbachir BenMohamed
Journal:  J Virol       Date:  2012-02-08       Impact factor: 5.103

3.  Nasolacrimal duct closure modulates ocular mucosal and systemic CD4(+) T-cell responses induced following topical ocular or intranasal immunization.

Authors:  Aziz Alami Chentoufi; Gargi Dasgupta; Anthony B Nesburn; Ilham Bettahi; Nicholas R Binder; Zareen S Choudhury; Winston D Chamberlain; Steven L Wechsler; Lbachir BenMohamed
Journal:  Clin Vaccine Immunol       Date:  2010-01-20

Review 4.  Asymptomatic memory CD8+ T cells: from development and regulation to consideration for human vaccines and immunotherapeutics.

Authors:  Arif Azam Khan; Ruchi Srivastava; Patricia Prado Lopes; Christine Wang; Thanh T Pham; Justin Cochrane; Nhi Thi Uyen Thai; Lucas Gutierrez; Lbachir Benmohamed
Journal:  Hum Vaccin Immunother       Date:  2014-02-05       Impact factor: 3.452

5.  Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: implication for the development of an universal CD8+ T-cell epitope-based vaccine.

Authors:  Sarah Samandary; Hédia Kridane-Miledi; Jacqueline S Sandoval; Zareen Choudhury; Francina Langa-Vives; Doran Spencer; Aziz A Chentoufi; François A Lemonnier; Lbachir BenMohamed
Journal:  Hum Immunol       Date:  2014-05-04       Impact factor: 2.850

6.  Unique Type I Interferon, Expansion/Survival Cytokines, and JAK/STAT Gene Signatures of Multifunctional Herpes Simplex Virus-Specific Effector Memory CD8+ TEM Cells Are Associated with Asymptomatic Herpes in Humans.

Authors:  Hawa Vahed; Anshu Agrawal; Ruchi Srivastava; Swayam Prakash; Pierre-Gregoire A Coulon; Soumyabrata Roy; Lbachir BenMohamed
Journal:  J Virol       Date:  2019-02-05       Impact factor: 5.103

7.  Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection.

Authors:  Anthony B Nesburn; Ilham Bettahi; Gargi Dasgupta; Alami Aziz Chentoufi; Xiuli Zhang; Sylvaine You; Naoyuki Morishige; Andrew J Wahlert; Donald J Brown; James V Jester; Steven L Wechsler; Lbachir BenMohamed
Journal:  J Virol       Date:  2007-05-02       Impact factor: 5.103

8.  Gender-dependent HLA-DR-restricted epitopes identified from herpes simplex virus type 1 glycoprotein D.

Authors:  Xiuli Zhang; Florence A Castelli; Xiaoming Zhu; Michele Wu; Bernard Maillère; Lbachir BenMohamed
Journal:  Clin Vaccine Immunol       Date:  2008-07-30

9.  Linear and branched glyco-lipopeptide vaccines follow distinct cross-presentation pathways and generate different magnitudes of antitumor immunity.

Authors:  Olivier Renaudet; Gargi Dasgupta; Ilham Bettahi; Alda Shi; Anthony B Nesburn; Pascal Dumy; Lbachir BenMohamed
Journal:  PLoS One       Date:  2010-06-21       Impact factor: 3.240

Review 10.  New concepts in herpes simplex virus vaccine development: notes from the battlefield.

Authors:  Gargi Dasgupta; Aziz A Chentoufi; Anthony B Nesburn; Steven L Wechsler; Lbachir BenMohamed
Journal:  Expert Rev Vaccines       Date:  2009-08       Impact factor: 5.217
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