Literature DB >> 17145935

CpG oligonucleotides improve the protective immune response induced by the licensed anthrax vaccine.

Dennis M Klinman1, Hang Xie, Bruce E Ivins.   

Abstract

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants, improving the response elicited by a coadministered vaccine. Combining CpG ODN with anthrax vaccine adsorbed (AVA, the licensed human vaccine) increases the speed, magnitude, and avidity of the resultant antibody response. IgG Abs against anthrax protective antigen (PA) protect mice, guinuea pigs, and rhesus macaques from infection.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17145935     DOI： 10.1196/annals.1348.030

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  16 in total

Review 1.  Modulating immunity as a therapy for bacterial infections.

Authors:  Robert E W Hancock; Anastasia Nijnik; Dana J Philpott
Journal:  Nat Rev Microbiol       Date:  2012-03-16       Impact factor: 60.633

Review 2.  Synthetic oligonucleotides as modulators of inflammation.

Authors:  Dennis Klinman; Hidekazu Shirota; Debra Tross; Takashi Sato; Sven Klaschik
Journal:  J Leukoc Biol       Date:  2008-04-22       Impact factor: 4.962

Review 3.  New developments in vaccines, inhibitors of anthrax toxins, and antibiotic therapeutics for Bacillus anthracis.

Authors:  J M Beierlein; A C Anderson
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

4.  Effect of suppressive oligodeoxynucleotides on the development of inflammation-induced papillomas.

Authors:  Hidekazu Ikeuchi; Takeshi Kinjo; Dennis M Klinman
Journal:  Cancer Prev Res (Phila)       Date:  2011-03-02

5.  Immunostimulatory CpG oligonucleotides: Effect on gene expression and utility as vaccine adjuvants.

Authors:  Dennis M Klinman; Sven Klaschik; Koji Tomaru; Hidekazu Shirota; Debra Tross; Hidekazu Ikeuchi
Journal:  Vaccine       Date:  2010-02-23       Impact factor: 3.641

6.  Rapid vaccination using an acetalated dextran microparticulate subunit vaccine confers protection against triplicate challenge by bacillus anthracis.

Authors:  Kevin L Schully; Sadhana Sharma; Kevin J Peine; John Pesce; Margret A Elberson; Mariko E Fonseca; Angela M Prouty; Matthew G Bell; Hassan Borteh; Matthew Gallovic; Eric M Bachelder; Andrea Keane-Myers; Kristy M Ainslie
Journal:  Pharm Res       Date:  2013-01-25       Impact factor: 4.200

7.  Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin.

Authors:  John M Thomas; Scott T Moen; Bryan T Gnade; Diego A Vargas-Inchaustegui; Sheri M Foltz; Giovanni Suarez; Hans W Heidner; Rolf König; Ashok K Chopra; Johnny W Peterson
Journal:  Clin Vaccine Immunol       Date:  2009-09-16

8.  Effect of CpG oligonucleotides on vaccine-induced B cell memory.

Authors:  Debra Tross; Dennis M Klinman
Journal:  J Immunol       Date:  2008-10-15       Impact factor: 5.422

9.  CpG oligodeoxynucleotides as immunotherapy in cancer.

Authors:  Bernd Jahrsdörfer; George J Weiner
Journal:  Update Cancer Ther       Date:  2008-03

10.  Protection Afforded by Fluoroquinolones in Animal Models of Respiratory Infections with Bacillus anthracis, Yersinia pestis, and Francisella tularensis.

Authors:  Johnny W Peterson; Scott T Moen; Daniel Healy; Jennifer E Pawlik; Joanna Taormina; Jason Hardcastle; John M Thomas; William S Lawrence; Cindy Ponce; Bagram M Chatuev; Bryan T Gnade; Sheri M Foltz; Stacy L Agar; Jian Sha; Gary R Klimpel; Michelle L Kirtley; Tonyia Eaves-Pyles; Ashok K Chopra
Journal:  Open Microbiol J       Date:  2010-06-03
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.