Literature DB >> 17145925

Inhibition of hepatitis C IRES-mediated gene expression by small hairpin RNAs in human hepatocytes and mice.

Heini Ilves1, Roger L Kaspar, Qian Wang, Attila A Seyhan, Alexander V Vlassov, Christopher H Contag, Devin Leake, Brian H Johnston.   

Abstract

The ability of small hairpin RNAs (shRNAs) to inhibit hepatitis C virus internal ribosome entry site (HCV IRES)-dependent gene expression was investigated in cultured cells and a mouse model. The results indicate that shRNAs, delivered as naked RNA or expressed from vectors, may be effective agents for the control of HCV and related viruses.

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Year:  2006        PMID： 17145925     DOI： 10.1196/annals.1348.060

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  8 in total

Review 1.  New therapeutic opportunities for hepatitis C based on small RNA.

Authors:  Qiu-Wei Pan; Scot D Henry; Bob J Scholte; Hugo W Tilanus; Harry L A Janssen; Luc J W van der Laan
Journal:  World J Gastroenterol       Date:  2007-09-07       Impact factor: 5.742

2.  Minimal-length short hairpin RNAs: the relationship of structure and RNAi activity.

Authors:  Qing Ge; Heini Ilves; Anne Dallas; Pavan Kumar; Joshua Shorenstein; Sergei A Kazakov; Brian H Johnston
Journal:  RNA       Date:  2009-12-01       Impact factor: 4.942

Review 3.  RNAi: a potential new class of therapeutic for human genetic disease.

Authors:  Attila A Seyhan
Journal:  Hum Genet       Date:  2011-05-03       Impact factor: 4.132

4.  Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy.

Authors:  Anne Dallas; Heini Ilves; Han Ma; Daniel J Chin; Ian Maclachlan; Klaus Klumpp; Brian H Johnston
Journal:  J Virol       Date:  2014-01-29       Impact factor: 5.103

Review 5.  Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site.

Authors:  Sergey M Dibrov; Jerod Parsons; Maia Carnevali; Shu Zhou; Kevin D Rynearson; Kejia Ding; Emily Garcia Sega; Nicholas D Brunn; Mark A Boerneke; Maria P Castaldi; Thomas Hermann
Journal:  J Med Chem       Date:  2013-11-05       Impact factor: 7.446

6.  Therapeutics Based on microRNA: A New Approach for Liver Cancer.

Authors:  G Zhang; Q Wang; R Xu
Journal:  Curr Genomics       Date:  2010-08       Impact factor: 2.236

7.  Combined antiviral activity of interferon-alpha and RNA interference directed against hepatitis C without affecting vector delivery and gene silencing.

Authors:  Qiuwei Pan; Scot D Henry; Herold J Metselaar; Bob Scholte; Jaap Kwekkeboom; Hugo W Tilanus; Harry L A Janssen; Luc J W van der Laan
Journal:  J Mol Med (Berl)       Date:  2009-04-30       Impact factor: 4.599

8.  Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice.

Authors:  Anne Dallas; Heini Ilves; Joshua Shorenstein; Adam Judge; Ryan Spitler; Christopher Contag; Suet Ping Wong; Richard P Harbottle; Ian Maclachlan; Brian H Johnston
Journal:  Mol Ther Nucleic Acids       Date:  2013-09-17       Impact factor: 10.183
  8 in total

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