Literature DB >> 17145803

Aurora kinases: new targets for cancer therapy.

Richard D Carvajal1, Archie Tse, Gary K Schwartz.   

Abstract

The Aurora kinase family is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis. In mammalian cells, Aurora has evolved into three related kinases known as Aurora-A, Aurora-B, and Aurora-C. These kinases are overexpressed in a number of human cancers, and transfection studies have established Aurora-A as a bone fide oncogene. Because Aurora overexpression is associated with malignancy, these kinases have been targeted for cancer therapy. This article reviews the multiple functions of Aurora kinase in the regulation of mitosis and the mitotic checkpoint, the role of abnormal Aurora kinase activity in the development of cancer, the putative mechanisms of Aurora kinase inhibition and its antitumor effects, the development of the first generation of Aurora kinase inhibitors, and prospects for the future of Aurora kinase inhibition in the treatment of cancer.

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Year:  2006        PMID： 17145803     DOI： 10.1158/1078-0432.CCR-06-1405

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  85 in total

1.  Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors.

Authors:  Gary K Schwartz; Richard D Carvajal; Rachel Midgley; Scott J Rodig; Paul K Stockman; Ozlem Ataman; David Wilson; Shampa Das; Geoffrey I Shapiro
Journal:  Invest New Drugs       Date:  2012-06-02       Impact factor: 3.850

Review 2.  Understanding cytokinesis failure.

Authors:  Guillaume Normand; Randall W King
Journal:  Adv Exp Med Biol       Date:  2010       Impact factor: 2.622

3.  RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells.

Authors:  Yinghui Fu; Jian Huang; Ke-Sheng Wang; Xin Zhang; Ze-Guang Han
Journal:  Mol Biol Rep       Date:  2010-04-06       Impact factor: 2.316

4.  Bioorthogonal imaging of aurora kinase A in live cells.

Authors:  Katherine S Yang; Ghyslain Budin; Thomas Reiner; Claudio Vinegoni; Ralph Weissleder
Journal:  Angew Chem Int Ed Engl       Date:  2012-05-29       Impact factor: 15.336

5.  Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780.

Authors:  Jayasree S Nair; Alan L Ho; Archie N Tse; Jesse Coward; Haider Cheema; Grazia Ambrosini; Nicholas Keen; Gary K Schwartz
Journal:  Mol Biol Cell       Date:  2009-02-18       Impact factor: 4.138

6.  Aurora-A kinase is essential for bipolar spindle formation and early development.

Authors:  Dale O Cowley; Jaime A Rivera-Pérez; Mark Schliekelman; Yizhou Joseph He; Trudy G Oliver; Lucy Lu; Ryan O'Quinn; E D Salmon; Terry Magnuson; Terry Van Dyke
Journal:  Mol Cell Biol       Date:  2008-12-15       Impact factor: 4.272

7.  Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells.

Authors:  Daniel R Premkumar; Esther P Jane; Ian F Pollack
Journal:  Cancer Biol Ther       Date:  2015       Impact factor: 4.742

Review 8.  Update on aurora kinase inhibitors in gynecologic malignancies.

Authors:  Xia Tao; Hye S Chon; Siqing Fu; John J Kavanagh; Wei Hu
Journal:  Recent Pat Anticancer Drug Discov       Date:  2008-11       Impact factor: 4.169

Review 9.  Chromatin-modifying enzymes as therapeutic targets--Part 2.

Authors:  Brian R Keppler; Trevor K Archer
Journal:  Expert Opin Ther Targets       Date:  2008-11       Impact factor: 6.902

Review 10.  Mitotic failures in cancer: Aurora B kinase and its potential role in the development of aneuploidy.

Authors:  Katalin Hegyi; Gábor Méhes
Journal:  Pathol Oncol Res       Date:  2012-07-29       Impact factor: 3.201
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