Literature DB >> 17145612

Constitutive activation of NF-kappa B is not sufficient to disturb normal steady-state hematopoiesis.

Hein Schepers, Bart J L Eggen, Jan Jacob Schuringa, Edo Vellenga.   

Abstract

Since nuclear factor-kappaB (NF-kappaB) is frequently activated in acute myeloid leukemia, we questioned whether active NF-kappaB can affect the cellular properties of cord blood CD34+ cells. The results demonstrated that NF-kappaB activation did not influence growth or differentiation properties of these cells. Furthermore, NF-kappaB activation was not sufficient to induce changes in stem- and progenitor cell numbers.

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Year:  2006        PMID： 17145612

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  6 in total

1.  ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human hematopoietic progenitor cell proliferation and differentiation into eosinophils: the role of nuclear factor-κB.

Authors:  Carmen P Montano-Almendras; Ahmed Essaghir; Hélène Schoemans; Inci Varis; Laura A Noël; Amélie I Velghe; Dominique Latinne; Laurent Knoops; Jean-Baptiste Demoulin
Journal:  Haematologica       Date:  2012-01-22       Impact factor: 9.941

Review 2.  Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes.

Authors:  I Gañán-Gómez; Y Wei; D T Starczynowski; S Colla; H Yang; M Cabrero-Calvo; Z S Bohannan; A Verma; U Steidl; G Garcia-Manero
Journal:  Leukemia       Date:  2015-03-12       Impact factor: 11.528

3.  IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis.

Authors:  Ferenc A Scheeren; Sean A Diehl; Laura A Smit; Tim Beaumont; Marianne Naspetti; Richard J Bende; Bianca Blom; Kennosuke Karube; Koichi Ohshima; Carel J M van Noesel; Hergen Spits
Journal:  Blood       Date:  2008-02-22       Impact factor: 22.113

4.  The role of NF-κB and Smac/DIABLO proteins in the treatment response and survival of acute myeloid leukemia patients.

Authors:  Agnieszka Pluta; Tadeusz Robak; Barbara Cebula; Agata Majchrzak; Piotr Pluta; Kamil Brzozowski; Konrad Stępka; Anna Szmigielska-Kapłon; Olga Grzybowska-Izydorczyk; Magdalena Czemerska; Piotr Smolewski; Agnieszka Wierzbowska
Journal:  Arch Med Sci       Date:  2019-11-19       Impact factor: 3.318

5.  Transient inhibition of NF-κB signaling enhances ex vivo propagation of human hematopoietic stem cells.

Authors:  Mehrnaz Safaee Talkhoncheh; Agatheeswaran Subramaniam; Mattias Magnusson; Praveen Kumar; Jonas Larsson; Aurélie Baudet
Journal:  Haematologica       Date:  2018-06-07       Impact factor: 9.941

6.  Overexpression of miR-125a in myelodysplastic syndrome CD34+ cells modulates NF-κB activation and enhances erythroid differentiation arrest.

Authors:  Irene Gañán-Gómez; Yue Wei; Hui Yang; Sherry Pierce; Carlos Bueso-Ramos; George Calin; María Del Carmen Boyano-Adánez; Guillermo García-Manero
Journal:  PLoS One       Date:  2014-04-01       Impact factor: 3.240
  6 in total

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