Literature DB >> 1714525

The vpx gene of simian immunodeficiency virus facilitates efficient viral replication in fresh lymphocytes and macrophage.

X F Yu1, Q C Yu, M Essex, T H Lee.   

Abstract

vpx is a unique open reading frame found in simian immunodeficiency virus (SIV) and human immunodeficiency virus type 2 (HIV-2) but not in HIV-1. It encodes a 12- to 16-kDa virion-associated protein. Although vpx is dispensable for viral replication in several established human lymphocyte cell lines, there is no consensus regarding whether this gene is required for efficient viral replication in freshly isolated lymphocytes. We report here that the vpx mutant of SIVmac exhibits different degrees of impairment from wild-type SIVmac in freshly isolated lymphocytes. This defect is more pronounced in macrophages from the same donors. Our findings suggest that vpx is required for efficient viral replication in fresh lymphocytes and macrophages.

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Year:  1991        PMID： 1714525      PMCID： PMC248975     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  Identification of HIV-1 vpr product and function.

Authors:  E A Cohen; E F Terwilliger; Y Jalinoos; J Proulx; J G Sodroski; W A Haseltine
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1990

2.  Analysis of the function of viral protein X (VPX) of HIV-2.

Authors:  W Hu; N Vander Heyden; L Ratner
Journal:  Virology       Date:  1989-12       Impact factor: 3.616

3.  A highly divergent HIV-2-related isolate.

Authors:  U Dietrich; M Adamski; R Kreutz; A Seipp; H Kühnel; H Rübsamen-Waigmann
Journal:  Nature       Date:  1989 Dec 21-28       Impact factor: 49.962

4.  Open reading frame vpr of simian immunodeficiency virus encodes a virion-associated protein.

Authors:  X F Yu; M Matsuda; M Essex; T H Lee
Journal:  J Virol       Date:  1990-11       Impact factor: 5.103

5.  Sequence of simian immunodeficiency virus from African green monkey, a new member of the HIV/SIV group.

Authors:  M Fukasawa; T Miura; A Hasegawa; S Morikawa; H Tsujimoto; K Miki; T Kitamura; M Hayami
Journal:  Nature       Date:  1988-06-02       Impact factor: 49.962

6.  Mutational analysis of the human immunodeficiency virus type 2 (HIV-2) genome in relation to HIV-1 and simian immunodeficiency virus SIV (AGM).

Authors:  R Shibata; T Miura; M Hayami; K Ogawa; H Sakai; T Kiyomasu; A Ishimoto; A Adachi
Journal:  J Virol       Date:  1990-02       Impact factor: 5.103

7.  Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III.

Authors:  P J Kanki; M F McLane; N W King; N L Letvin; R D Hunt; P Sehgal; M D Daniel; R C Desrosiers; M Essex
Journal:  Science       Date:  1985-06-07       Impact factor: 47.728

8.  Isolation and characterization of a novel protein (X-ORF product) from SIV and HIV-2.

Authors:  L E Henderson; R C Sowder; T D Copeland; R E Benveniste; S Oroszlan
Journal:  Science       Date:  1988-07-08       Impact factor: 47.728

9.  Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses.

Authors:  L Chakrabarti; M Guyader; M Alizon; M D Daniel; R C Desrosiers; P Tiollais; P Sonigo
Journal:  Nature       Date:  1987 Aug 6-12       Impact factor: 49.962

10.  VPX mutants of HIV-2 are infectious in established cell lines but display a severe defect in peripheral blood lymphocytes.

Authors:  M Guyader; M Emerman; L Montagnier; K Peden
Journal:  EMBO J       Date:  1989-04       Impact factor: 11.598
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  53 in total

1.  A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation.

Authors:  Wei Wei; Haoran Guo; Xianjun Liu; Hong Zhang; Lei Qian; Kun Luo; Richard B Markham; Xiao-Fang Yu
Journal:  J Virol       Date:  2013-10-23       Impact factor: 5.103

2.  Vpx is critical for reverse transcription of the human immunodeficiency virus type 2 genome in macrophages.

Authors:  Mikako Fujita; Masami Otsuka; Masami Miyoshi; Boonruang Khamsri; Masako Nomaguchi; Akio Adachi
Journal:  J Virol       Date:  2008-05-21       Impact factor: 5.103

3.  Variation of two primate lineage-specific residues in human SAMHD1 confers resistance to N terminus-targeted SIV Vpx proteins.

Authors:  Wei Wei; Haoran Guo; Qimeng Gao; Richard Markham; Xiao-Fang Yu
Journal:  J Virol       Date:  2013-10-30       Impact factor: 5.103

4.  Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx.

Authors:  Patrick A Cassiday; Ana Beatriz DePaula-Silva; Jeffrey Chumley; Jeffrey Ward; Edward Barker; Vicente Planelles
Journal:  Virology       Date:  2014-12-11       Impact factor: 3.616

5.  A virion-specific inhibitory molecule with therapeutic potential for human immunodeficiency virus type 1.

Authors:  Z Matsuda; X Yu; Q C Yu; T H Lee; M Essex
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

6.  A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects.

Authors:  I G Macreadie; L A Castelli; D R Hewish; A Kirkpatrick; A C Ward; A A Azad
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

7.  Vpr-induced cell cycle arrest is conserved among primate lentiviruses.

Authors:  V Planelles; J B Jowett; Q X Li; Y Xie; B Hahn; I S Chen
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

8.  Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.

Authors:  Caroline Goujon; Vanessa Arfi; Thomas Pertel; Jeremy Luban; Julia Lienard; Dominique Rigal; Jean-Luc Darlix; Andrea Cimarelli
Journal:  J Virol       Date:  2008-10-01       Impact factor: 5.103

Review 9.  Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr?

Authors:  Diana Ayinde; Claire Maudet; Catherine Transy; Florence Margottin-Goguet
Journal:  Retrovirology       Date:  2010-04-09       Impact factor: 4.602

10.  Induction of inflammation by West Nile virus capsid through the caspase-9 apoptotic pathway.

Authors:  Joo-Sung Yang; Mathura P Ramanathan; Karuppiah Muthumani; Andrew Y Choo; Sung-Ha Jin; Qian-Chun Yu; Daniel S Hwang; Daniel K Choo; Mark D Lee; Kesen Dang; Waixing Tang; J Joseph Kim; David B Weiner
Journal:  Emerg Infect Dis       Date:  2002-12       Impact factor: 6.883
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