| Literature DB >> 17145130 |
Philippe Delvenne1, Ludivine Herman, Natalia Kholod, Jean-Hubert Caberg, Michaël Herfs, Jacques Boniver, Nathalie Jacobs, Pascale Hubert.
Abstract
If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, interactions between steroid hormones and HPV gene expression and alterations of the local immune microenvironment.Entities:
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Year: 2006 PMID： 17145130 DOI： 10.1016/j.mce.2006.10.014
Source DB: PubMed Journal: Mol Cell Endocrinol ISSN： 0303-7207 Impact factor: 4.102