Literature DB >> 17143818

Low sensitivity of a whole-blood interferon-gamma release assay for detection of active tuberculosis.

Puneet K Dewan1, Jennifer Grinsdale, L Masae Kawamura.   

Abstract

The sensitivity of an interferon-gamma assay (Quantiferon-TB Gold; Cellestis) was evaluated for the detection of tuberculosis among 242 persons with suspected tuberculosis in San Francisco, California. Thirty-seven subjects had culture-confirmed tuberculosis. Excluding 1 indeterminate result, 23 (64%; 95% confidence interval, 48%-78%) of 36 subjects had positive results using the QuantiFERON-TB Gold assay. The 64% sensitivity suggests that the QuantiFERON-TB Gold assay should not be used alone to exclude active tuberculosis.

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Year:  2006        PMID： 17143818     DOI： 10.1086/509928

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  39 in total

1.  Reproducibility of QuantiFERON-TB gold in-tube assay.

Authors:  Sharon Perry; Luz Sanchez; Shufang Yang; Zubin Agarwal; Philip Hurst; Julie Parsonnet
Journal:  Clin Vaccine Immunol       Date:  2008-01-16

2.  Cerebrospinal T-cell responses aid in the diagnosis of tuberculous meningitis in a human immunodeficiency virus- and tuberculosis-endemic population.

Authors:  Vinod B Patel; Ravesh Singh; Cathy Connolly; Yacoob Coovadia; Abdool K C Peer; Priyashini Parag; Victoria Kasprowicz; Alimuddin Zumla; Thumbi Ndung'u; Keertan Dheda
Journal:  Am J Respir Crit Care Med       Date:  2010-05-04       Impact factor: 21.405

3.  Are interferon-γ release assays useful for diagnosing active tuberculosis in a high-burden setting?

Authors:  D I Ling; M Pai; V Davids; L Brunet; L Lenders; R Meldau; G Calligaro; B Allwood; R van Zyl-Smit; J Peter; E Bateman; R Dawson; K Dheda
Journal:  Eur Respir J       Date:  2011-02-24       Impact factor: 16.671

4.  Serial interferon-gamma release assays during treatment of active tuberculosis in young adults.

Authors:  Sei Won Lee; Choon-Taek Lee; Jae-Joon Yim
Journal:  BMC Infect Dis       Date:  2010-10-16       Impact factor: 3.090

5.  Sensitivity of the quantiferon-gold in-tube assay in sputum smear positive TB cases in Indonesia.

Authors:  Merrin Rutherford; Bachti Alisjahbana; Winni Maharani; Hedy Sampurno; Reinout van Crevel; Philip C Hill
Journal:  PLoS One       Date:  2010-08-09       Impact factor: 3.240

6.  Determinants of natural immunity against tuberculosis in an endemic setting: factors operating at the level of macrophage-Mycobacterium tuberculosis interaction.

Authors:  A N Gaikwad; Sudhir Sinha
Journal:  Clin Exp Immunol       Date:  2008-03       Impact factor: 4.330

7.  Use of whole-blood samples in in-house bulk and single-cell antigen-specific gamma interferon assays for surveillance of Mycobacterium tuberculosis infections.

Authors:  Raffaella Palazzo; Fabiana Spensieri; Marco Massari; Giorgio Fedele; Loredana Frasca; Stefania Carrara; Delia Goletti; Clara M Ausiello
Journal:  Clin Vaccine Immunol       Date:  2007-11-21

Review 8.  Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update.

Authors:  Madhukar Pai; Alice Zwerling; Dick Menzies
Journal:  Ann Intern Med       Date:  2008-06-30       Impact factor: 25.391

Review 9.  [Interferon-gamma release assays in tuberculosis diagnostics].

Authors:  H Hoffmann; G Loytved; T Bodmer
Journal:  Internist (Berl)       Date:  2007-05       Impact factor: 0.743

10.  Use of a T cell interferon gamma release assay in the investigation for suspected active tuberculosis in a low prevalence area.

Authors:  Niclas Winqvist; Per Björkman; Ann Norén; Håkan Miörner
Journal:  BMC Infect Dis       Date:  2009-07-03       Impact factor: 3.090
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