Yan Wang1, Xueqiang Fang, Shumei Wang, Yueqiu Feng, Jinghai Yin. 1. Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, no.44 Wen Hua Xi Road, Jinan, Shandong 250012, People's Republic of China.
Abstract
OBJECTIVES: To investigate the possible relationship between circulating oxLDL and oxLDL Ab concentrations in order to better understand the role of oxLDL Ab in atherosclerosis. DESIGN: In a cross-sectional study of 86 patients undergoing ultrasonographic scanning of the carotid artery, concentration of circulating oxLDL and oxLDL Ab were determined by ELISA. For multivariate analysis, we also measured many conventional cardiovascular risk factors. Spearman's rank correlation test and chi-square test were used to evaluate the correlation between circulating oxLDL and oxLDL Ab. A stepwise multiple regression analysis and Logistic regression analysis were used to study the influencing factors. RESULTS: There was no linear correlation between circulating oxLDL and oxLDL Ab. Circulating oxLDL was influenced by HDL, systolic blood pressure and body mass index, while only TC was independent factor associating with oxLDL Ab. CONCLUSIONS: The present study showed that oxLDL was present at a low concentration in the circulation, and that plasma oxLDL had no linear correlation with oxLDL antibodies. However, the issue still needs further study.
OBJECTIVES: To investigate the possible relationship between circulating oxLDL and oxLDL Ab concentrations in order to better understand the role of oxLDL Ab in atherosclerosis. DESIGN: In a cross-sectional study of 86 patients undergoing ultrasonographic scanning of the carotid artery, concentration of circulating oxLDL and oxLDL Ab were determined by ELISA. For multivariate analysis, we also measured many conventional cardiovascular risk factors. Spearman's rank correlation test and chi-square test were used to evaluate the correlation between circulating oxLDL and oxLDL Ab. A stepwise multiple regression analysis and Logistic regression analysis were used to study the influencing factors. RESULTS: There was no linear correlation between circulating oxLDL and oxLDL Ab. Circulating oxLDL was influenced by HDL, systolic blood pressure and body mass index, while only TC was independent factor associating with oxLDL Ab. CONCLUSIONS: The present study showed that oxLDL was present at a low concentration in the circulation, and that plasma oxLDL had no linear correlation with oxLDL antibodies. However, the issue still needs further study.
Authors: James C Fang; Scott Kinlay; Dominik Behrendt; Hiroyuki Hikita; Joseph L Witztum; Andrew P Selwyn; Peter Ganz Journal: Arterioscler Thromb Vasc Biol Date: 2002-12-01 Impact factor: 8.311
Authors: Gian Paolo Rossi; Maurizio Cesari; Renzo De Toni; Mario Zanchetta; Giuseppe Maiolino; Luigi Pedon; Chiara Ganzaroli; Pietro Maiolino; Achille C Pessina Journal: Circulation Date: 2003-10-27 Impact factor: 29.690
Authors: M Schumacher; B Eber; F Tatzber; P Kaufmann; G Halwachs; F M Fruhwald; R Zweiker; H Esterbauer; W Klein Journal: Free Radic Biol Med Date: 1995-06 Impact factor: 7.376
Authors: Jonathan Watt; Simon Kennedy; Nadeem Ahmed; James Hayhurst; John D McClure; Colin Berry; Roger M Wadsworth; Keith G Oldroyd Journal: Open Heart Date: 2016-01-28