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Literature DB >> 17142859

The contribution of epidermal stem cells to skin cancer.

Abstract

Tumors arising from the skin are of multiple phenotypes, with differing degrees of malignant potential. In mouse models of skin carcinogenesis, tumors of squamous phenotype are the most common; however, human disease indicates that multiple phenotypes may arise from a common pool of stem cells that are then influenced by epigenetic factors. The use of transgenic and knockout gene technologies with mice is unraveling some of the specific genes regulating fate determination in stem cells other than squamous lineage, including basal cell carcinoma and sebaceous adenomas. The following review examines the evidence for the stem cell origin of epidermal tumors and the contribution of some specific gene families toward stem cell fate decisions during epidermal tumor progression.

Entities: Disease Species

Mesh：

Year: 2005 PMID： 17142859 DOI： 10.1385/SCR:1:3:225

Source DB: PubMed Journal: Stem Cell Rev ISSN： 1550-8943 Impact factor: 5.739

92 in total

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Authors: R Parsa; A Yang; F McKeon; H Green
Journal: J Invest Dermatol Date: 1999-12 Impact factor: 8.551

2. Telomerase activity in Kaposi's sarcoma, squamous cell carcinoma, and basal cell carcinoma.

Authors: Z Chen; K J Smith; H G Skelton; T L Barrett; H T Greenway; S C Lo
Journal: Exp Biol Med (Maywood) Date: 2001-09

3. The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation.

Authors: F Mainiero; C Murgia; K K Wary; A M Curatola; A Pepe; M Blumemberg; J K Westwick; C J Der; F G Giancotti
Journal: EMBO J Date: 1997-05-01 Impact factor: 11.598

4. Quantitation of primary in vitro clonogenic keratinocytes from normal adult murine epidermis, following initiation, and during promotion of epidermal tumors.

Authors: R J Morris; K C Tacker; S M Fischer; T J Slaga
Journal: Cancer Res Date: 1988-11-15 Impact factor: 12.701

5. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

Authors: E González-Suárez; E Samper; J M Flores; M A Blasco
Journal: Nat Genet Date: 2000-09 Impact factor: 38.330

6. c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny.

Authors: I Arnold; F M Watt
Journal: Curr Biol Date: 2001-04-17 Impact factor: 10.834

7. Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours.

Authors: Cristina Lo Celso; David M Prowse; Fiona M Watt
Journal: Development Date: 2004-04 Impact factor: 6.868

8. Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis.

Authors: Karin Muller-Decker; Gitta Neufang; Irina Berger; Melanie Neumann; Friedrich Marks; Gerhard Furstenberger
Journal: Proc Natl Acad Sci U S A Date: 2002-09-09 Impact factor: 11.205

9. Essential role for Sonic hedgehog during hair follicle morphogenesis.

Authors: C Chiang; R Z Swan; M Grachtchouk; M Bolinger; Y Litingtung; E K Robertson; M K Cooper; W Gaffield; H Westphal; P A Beachy; A A Dlugosz
Journal: Dev Biol Date: 1999-01-01 Impact factor: 3.582

10. Side population cells in human and mouse epidermis lack stem cell characteristics.

Authors: Charlotte Triel; Malene Eun Vestergaard; Lars Bolund; Thomas Gryesten Jensen; Uffe Birk Jensen
Journal: Exp Cell Res Date: 2004-04-15 Impact factor: 3.905

13 in total

1. Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic.

Authors: Yang Sun; Erik J Tokar; Michael P Waalkes
Journal: Toxicol Sci Date: 2011-10-19 Impact factor: 4.849

Review 2. Keratinocyte stem cells and the targets for nonmelanoma skin cancer.

Authors: Ashok Singh; Heuijoon Park; Thaned Kangsamaksin; Anupama Singh; Nyssa Readio; Rebecca J Morris
Journal: Photochem Photobiol Date: 2012-01-31 Impact factor: 3.421

3. A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse.

Authors: Shulan Li; Heuijoon Park; Carol S Trempus; Derek Gordon; Yaping Liu; George Cotsarelis; Rebecca J Morris
Journal: Mol Carcinog Date: 2012-03-16 Impact factor: 4.784

4. Are stem cell niches shared for skin cancers?

Authors: Neil F Box; Enrique C Torchia; Dennis R Roop
Journal: Pigment Cell Melanoma Res Date: 2010-06-08 Impact factor: 4.693

Review 5. Biochemistry of epidermal stem cells.

Authors: Richard L Eckert; Gautam Adhikary; Sivaprakasam Balasubramanian; Ellen A Rorke; Mohan C Vemuri; Shayne E Boucher; Jackie R Bickenbach; Candace Kerr
Journal: Biochim Biophys Acta Date: 2012-07-20

6. Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics.

Authors: Michael P Waalkes; Jie Liu; Dori R Germolec; Carol S Trempus; Ronald E Cannon; Erik J Tokar; Raymond W Tennant; Jerrold M Ward; Bhalchandra A Diwan
Journal: Cancer Res Date: 2008-10-15 Impact factor: 12.701

7. Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis.

Authors: Yang Sun; Jingbo Pi; Xueqian Wang; Erik J Tokar; Jie Liu; Michael P Waalkes
Journal: Toxicology Date: 2009-06-12 Impact factor: 4.221