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Literature DB >> 17142849

Manipulation of the human genome in human embryonic stem cells.

Abstract

Human embryonic stem cells (HESCs) have a tremendous clinical and scientific importance since they may serve as a cell source for transplantation and as a system for the study of human development and disease. The genetic engineering of HESCs has become instrumental in achieving these goals. Here we discuss various methodologies to genetically manipulate HESCs and propose a variety of applications of the modified cells in basic and applied research.

Entities: Species

Mesh：

Year: 2005 PMID： 17142849 DOI： 10.1385/SCR:1:2:145

Source DB: PubMed Journal: Stem Cell Rev ISSN： 1550-8943 Impact factor: 5.739

30 in total

1. RET: a poly A-trap retrovirus vector for reversible disruption and expression monitoring of genes in living cells.

Authors: Y Ishida; P Leder
Journal: Nucleic Acids Res Date: 1999-12-15 Impact factor: 16.971

2. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells.

Authors: M Schuldiner; O Yanuka; J Itskovitz-Eldor; D A Melton; N Benvenisty
Journal: Proc Natl Acad Sci U S A Date: 2000-10-10 Impact factor: 11.205

3. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

Authors: A Fire; S Xu; M K Montgomery; S A Kostas; S E Driver; C C Mello
Journal: Nature Date: 1998-02-19 Impact factor: 49.962

4. Involvement of hepatocyte nuclear factor 3 in endoderm differentiation of embryonic stem cells.

Authors: M Levinson-Dushnik; N Benvenisty
Journal: Mol Cell Biol Date: 1997-07 Impact factor: 4.272

5. Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells.

Authors: M Tada; Y Takahama; K Abe; N Nakatsuji; T Tada
Journal: Curr Biol Date: 2001-10-02 Impact factor: 10.834

6. Stable genetic modification of human embryonic stem cells by lentiviral vectors.

Authors: Michal Gropp; Pavel Itsykson; Orna Singer; Tamir Ben-Hur; Etti Reinhartz; Eithan Galun; Benjamin E Reubinoff
Journal: Mol Ther Date: 2003-02 Impact factor: 11.454

7. Embryonic stem cell lines derived from human blastocysts.

Authors: J A Thomson; J Itskovitz-Eldor; S S Shapiro; M A Waknitz; J J Swiergiel; V S Marshall; J M Jones
Journal: Science Date: 1998-11-06 Impact factor: 47.728

8. Gene trap as a tool for genome annotation and analysis of X chromosome inactivation in human embryonic stem cells.

Authors: Sujoy K Dhara; Nissim Benvenisty
Journal: Nucleic Acids Res Date: 2004-07-29 Impact factor: 16.971

9. Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst.

Authors: Woo Suk Hwang; Young June Ryu; Jong Hyuk Park; Eul Soon Park; Eu Gene Lee; Ja Min Koo; Hyun Yong Jeon; Byeong Chun Lee; Sung Keun Kang; Sun Jong Kim; Curie Ahn; Jung Hye Hwang; Ky Young Park; Jose B Cibelli; Shin Yong Moon
Journal: Science Date: 2004-02-12 Impact factor: 47.728

10. Enhancing and diminishing gene function in human embryonic stem cells.

Authors: Ludovic Vallier; Peter J Rugg-Gunn; Isabelle A Bouhon; Frida K Andersson; Amanda J Sadler; Roger A Pedersen
Journal: Stem Cells Date: 2004 Impact factor: 6.277

1 in total

1. Studying early lethality of 45,XO (Turner's syndrome) embryos using human embryonic stem cells.

Authors: Achia Urbach; Nissim Benvenisty
Journal: PLoS One Date: 2009-01-12 Impact factor: 3.240

1 in total