Literature DB >> 17142397

Role of phosphoenolpyruvate in the NADP-isocitrate dehydrogenase and isocitrate lyase reaction in Escherichia coli.

Tadashi Ogawa1, Keiko Murakami, Hirotada Mori, Nobuyoshi Ishii, Masaru Tomita, Masataka Yoshin.   

Abstract

Phosphoenolpyruvate inhibited Escherichia coli NADP-isocitrate dehydrogenase allosterically (Ki of 0.31 mM) and isocitrate lyase uncompetitively (Ki' of 0.893 mM). Phosphoenolpyruvate enhances the uncompetitive inhibition of isocitrate lyase by increasing isocitrate, which protects isocitrate dehydrogenase from the inhibition, and contributes to the control through the tricarboxylic acid cycle and glyoxylate shunt.

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Year:  2006        PMID: 17142397      PMCID: PMC1797289          DOI: 10.1128/JB.01628-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN: 0021-9193            Impact factor:   3.490


  14 in total

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Review 2.  The central metabolic pathways of Escherichia coli: relationship between flux and control at a branch point, efficiency of conversion to biomass, and excretion of acetate.

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Journal:  Curr Top Cell Regul       Date:  1986

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Authors:  D Blangy; H Buc; J Monod
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Authors:  M Yoshino; Y Yamada; K Murakami
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9.  In vivo phosphorylation of isocitrate lyase from Escherichia coli D5H3G7.

Authors:  J C Hoyt; H C Reeves
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