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Literature DB >> 17142378

Chronic Helicobacter pylori infection does not significantly alter the microbiota of the murine stomach.

Mai Ping Tan¹, Maria Kaparakis, Maja Galic, John Pedersen, Martin Pearse, Odilia L C Wijburg, Peter H Janssen, Richard A Strugnell.

Abstract

We examined the impact of Helicobacter pylori infection on the murine gastric microbiota by culture and terminal-restriction fragment length polymorphism and found that neither acute nor chronic H. pylori infection substantially affected the gastric microbial composition. Interestingly, the total H. pylori burden detected by real-time PCR was significantly higher than that revealed by viable counts, suggesting that the antigenic load sustaining H. pylori-induced gastritis could be considerably higher than previously believed.

Entities: Disease Species

Mesh：

Year: 2006 PMID： 17142378 PMCID： PMC1800740 DOI： 10.1128/AEM.01675-06

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

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