Literature DB >> 17142111

Human MutLalpha: the jack of all trades in MMR is also an endonuclease.

Wei Yang1.   

Abstract

Recently, Paul Modrich's group reported the discovery of an intrinsic endonuclease activity for human MutLalpha. This breakthrough provides a satisfactory answer to the longstanding puzzle of a missing nuclease activity in human mismatch repair and will undoubtedly lead to new investigations of DNA repair and replication. Here, the implications of this exciting new finding are discussed in the context of mismatch repair in Escherichia coli and humans.

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Year:  2006        PMID： 17142111      PMCID： PMC1847629          DOI： 10.1016/j.dnarep.2006.10.021

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  34 in total

Review 1.  DNA polymerase clamp loaders and DNA recognition.

Authors:  Gregory D Bowman; Eric R Goedken; Steven L Kazmirski; Mike O'Donnell; John Kuriyan
Journal:  FEBS Lett       Date:  2005-02-07       Impact factor: 4.124

2.  MutH complexed with hemi- and unmethylated DNAs: coupling base recognition and DNA cleavage.

Authors:  Jae Young Lee; Judy Chang; Nimesh Joseph; Rodolfo Ghirlando; Desirazu N Rao; Wei Yang
Journal:  Mol Cell       Date:  2005-10-07       Impact factor: 17.970

3.  Reconstitution of 5'-directed human mismatch repair in a purified system.

Authors:  Yanbin Zhang; Fenghua Yuan; Steven R Presnell; Keli Tian; Yin Gao; Alan E Tomkinson; Liya Gu; Guo-Min Li
Journal:  Cell       Date:  2005-09-09       Impact factor: 41.582

4.  Analysis of the quaternary structure of the MutL C-terminal domain.

Authors:  Jan Kosinski; Ina Steindorf; Janusz M Bujnicki; Luis Giron-Monzon; Peter Friedhoff
Journal:  J Mol Biol       Date:  2005-08-26       Impact factor: 5.469

5.  Endonucleolytic function of MutLalpha in human mismatch repair.

Authors:  Farid A Kadyrov; Leonid Dzantiev; Nicoleta Constantin; Paul Modrich
Journal:  Cell       Date:  2006-07-28       Impact factor: 41.582

Review 6.  DNA mismatch repair: functions and mechanisms.

Authors:  Ravi R Iyer; Anna Pluciennik; Vickers Burdett; Paul L Modrich
Journal:  Chem Rev       Date:  2006-02       Impact factor: 60.622

Review 7.  Lynch syndrome genes.

Authors:  Päivi Peltomäki
Journal:  Fam Cancer       Date:  2005       Impact factor: 2.375

8.  Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair.

Authors:  C Ban; M Junop; W Yang
Journal:  Cell       Date:  1999-04-02       Impact factor: 41.582

9.  DNA mismatch correction in a defined system.

Authors:  R S Lahue; K G Au; P Modrich
Journal:  Science       Date:  1989-07-14       Impact factor: 47.728

10.  Identifying an interaction site between MutH and the C-terminal domain of MutL by crosslinking, affinity purification, chemical coding and mass spectrometry.

Authors:  Robert Ahrends; Jan Kosinski; Dieter Kirsch; Laura Manelyte; Luis Giron-Monzon; Lars Hummerich; Oliver Schulz; Bernhard Spengler; Peter Friedhoff
Journal:  Nucleic Acids Res       Date:  2006-06-13       Impact factor: 16.971
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  11 in total

1.  Evidence for ATP-dependent structural rearrangement of nuclease catalytic site in DNA mismatch repair endonuclease MutL.

Authors:  Tatsuya Yamamoto; Hitoshi Iino; Kwang Kim; Seiki Kuramitsu; Kenji Fukui
Journal:  J Biol Chem       Date:  2011-09-26       Impact factor: 5.157

2.  Small-angle X-ray scattering analysis reveals the ATP-bound monomeric state of the ATPase domain from the homodimeric MutL endonuclease, a GHKL phosphotransferase superfamily protein.

Authors:  Hitoshi Iino; Takaaki Hikima; Yuya Nishida; Masaki Yamamoto; Seiki Kuramitsu; Kenji Fukui
Journal:  Extremophiles       Date:  2015-03-26       Impact factor: 2.395

Review 3.  Endonuclease activities of MutLα and its homologs in DNA mismatch repair.

Authors:  Lyudmila Y Kadyrova; Farid A Kadyrov
Journal:  DNA Repair (Amst)       Date:  2015-12-02

4.  Proteasome inhibition rescues clinically significant unstable variants of the mismatch repair protein Msh2.

Authors:  Tim Arlow; Kristan Scott; Aubrey Wagenseller; Alison Gammie
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-17       Impact factor: 11.205

5.  The C-terminal domain of the MutL homolog from Neisseria gonorrhoeae forms an inverted homodimer.

Authors:  Sivakumar Namadurai; Deepti Jain; Dhananjay S Kulkarni; Chaitanya R Tabib; Peter Friedhoff; Desirazu N Rao; Deepak T Nair
Journal:  PLoS One       Date:  2010-10-28       Impact factor: 3.240

6.  Embryonic lethality after combined inactivation of Fancd2 and Mlh1 in mice.

Authors:  Henri J van de Vrugt; Laura Eaton; Amy Hanlon Newell; Mushen Al-Dhalimy; R Michael Liskay; Susan B Olson; Markus Grompe
Journal:  Cancer Res       Date:  2009-12-15       Impact factor: 12.701

7.  Structural Features and Functional Dependency on β-Clamp Define Distinct Subfamilies of Bacterial Mismatch Repair Endonuclease MutL.

Authors:  Kenji Fukui; Seiki Baba; Takashi Kumasaka; Takato Yano
Journal:  J Biol Chem       Date:  2016-07-01       Impact factor: 5.157

Review 8.  Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair.

Authors:  Marlo K Thompson; Robert W Sobol; Aishwarya Prakash
Journal:  Biology (Basel)       Date:  2021-06-14

9.  DNA mismatch repair in eukaryotes and bacteria.

Authors:  Kenji Fukui
Journal:  J Nucleic Acids       Date:  2010-07-27

10.  Adenosine triphosphate stimulates Aquifex aeolicus MutL endonuclease activity.

Authors:  Jerome Mauris; Thomas C Evans
Journal:  PLoS One       Date:  2009-09-24       Impact factor: 3.240
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