Literature DB >> 17141755

Nonlinear isobologram and superadditive withdrawal from cocaine: cannabinoid combinations in planarians.

Robert B Raffa1, Gregory W Stagliano, Ronald J Tallarida.   

Abstract

Elucidation of interactions between drugs used in polydrug abuse is especially important. However, the necessary experimental conditions for precise quantitative analysis are difficult to establish. Because withdrawal effects of cocaine and the cannabinoid receptor agonist WIN 55212-2 are easily quantified in planarians, demonstration of synergistic effects (P<0.01) of certain ratios of this combination was possible. This synergy, here analyzed with the latest (nonlinear) isobolographic methodology, is now quantitatively established for the first time.

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Year:  2006        PMID： 17141755      PMCID： PMC1866290          DOI： 10.1016/j.ejphar.2006.10.051

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Isobolographic analysis for combinations of a full and partial agonist: curved isoboles.

Authors:  Yury Grabovsky; Ronald J Tallarida
Journal:  J Pharmacol Exp Ther       Date:  2004-06-02       Impact factor: 4.030

2.  Description and quantification of cocaine withdrawal signs in Planaria.

Authors:  Robert B Raffa; Prarthna Desai
Journal:  Brain Res       Date:  2005-01-25       Impact factor: 3.252

3.  An overview of drug combination analysis with isobolograms.

Authors:  Ronald J Tallarida
Journal:  J Pharmacol Exp Ther       Date:  2006-05-02       Impact factor: 4.030

4.  Proposal of a new model with dopaminergic-cholinergic interactions for neuropharmacological investigations.

Authors:  A Carolei; V Margotta; G Palladini
Journal:  Neuropsychobiology       Date:  1975       Impact factor: 2.328

5.  A nitric oxide synthase inhibitor (L-NAME) attenuates abstinence-induced withdrawal from both cocaine and a cannabinoid agonist (WIN 55212-2) in Planaria.

Authors:  Scott M Rawls; Tonatiu Rodriguez; David A Baron; Robert B Raffa
Journal:  Brain Res       Date:  2006-06-19       Impact factor: 3.252

6.  Cocaine withdrawal in Planaria.

Authors:  R B Raffa; J M Valdez
Journal:  Eur J Pharmacol       Date:  2001-10-26       Impact factor: 4.432

7.  A pharmacological study of dopaminergic receptors in planaria.

Authors:  G Venturini; F Stocchi; V Margotta; S Ruggieri; D Bravi; P Bellantuono; G Palladini
Journal:  Neuropharmacology       Date:  1989-12       Impact factor: 5.250
  7 in total
  4 in total

1.  Cocaine synergism with α agonists in rat aorta: computational analysis reveals an action beyond reuptake inhibition.

Authors:  Neil S Lamarre; Robert B Raffa; Ronald J Tallarida
Journal:  Drug Alcohol Depend       Date:  2012-12-25       Impact factor: 4.492

2.  The kappa-opioid receptor antagonist nor-BNI inhibits cocaine and amphetamine, but not cannabinoid (WIN 52212-2), abstinence-induced withdrawal in planarians: an instance of 'pharmacologic congruence'.

Authors:  Robert B Raffa; Gregory W Stagliano; Geoffrey Ross; Jenay A Powell; Austin G Phillips; Zhe Ding; Scott M Rawls
Journal:  Brain Res       Date:  2007-12-08       Impact factor: 3.252

Review 3.  Isobologram Analysis: A Comprehensive Review of Methodology and Current Research.

Authors:  Ruo-Yue Huang; Linlin Pei; QuanJin Liu; Shiqi Chen; Haibo Dou; Gang Shu; Zhi-Xiang Yuan; Juchun Lin; Guangneng Peng; Wei Zhang; Hualin Fu
Journal:  Front Pharmacol       Date:  2019-10-29       Impact factor: 5.810

Review 4.  The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration.

Authors:  Tristyn L Clarke; Rachael L Johnson; Jonathan J Simone; Robert L Carlone
Journal:  Int J Mol Sci       Date:  2021-02-20       Impact factor: 5.923
  4 in total

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