Literature DB >> 17139116

Asymmetric construction of quaternary carbon stereocenter by Pd-catalyzed intramolecular alpha-arylation.

Takafumi Arao1, Kazuhiro Kondo, Toyohiko Aoyama.   

Abstract

The catalyst comprised of Pd(OAc)(2) and H(8)-BINAP provides good reaction conversions for a catalytic enantioselective intramolecular alpha-arylation of N-(2-bromophenyl)-N-methyl-2-arylpropanamide to form the quaternary carbon with up to 68% enantioselectivity.

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Year:  2006        PMID: 17139116     DOI: 10.1248/cpb.54.1743

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  2 in total

1.  Asymmetric palladium-catalyzed intramolecular alpha-arylation of aldehydes.

Authors:  Jorge García-Fortanet; Stephen L Buchwald
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

2.  Enantioselective alpha-arylation of ketones with aryl triflates catalyzed by difluorphos complexes of palladium and nickel.

Authors:  Xuebin Liao; Zhiqiang Weng; John F Hartwig
Journal:  J Am Chem Soc       Date:  2007-12-13       Impact factor: 15.419

  2 in total

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