Literature DB >> 17137636

Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity.

Chris A Learn1, Peter M Grossi, Robert J Schmittling, Weihua Xie, Duane A Mitchell, Isaac Karikari, ZhengZheng Wei, Holly Dressman, John H Sampson.   

Abstract

For the study of malignant glioma, we have previously characterized a highly tumorigenic murine astrocytoma, SMA-560, which arose spontaneously in an inbred, immunocompetent VM/Dk mouse. Using this cell line as a model of murine glioma, we performed DNA microarray analysis of autologous normal murine astroctyes (NMA) and SMA-560 tumor cells grown in monolayer culture or intracranially in syngeneic immunocompetent or immunocompromised hosts in order to determine whether tumors grown in vitro recreate the complex genetic regulation that occurs in vivo. Our findings support our hypothesis that glioma phenotype in vitro may be quite different in vivo and significantly altered by in situ growth factors and other invading cell populations.

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Year:  2006        PMID： 17137636      PMCID： PMC1865509          DOI： 10.1016/j.jneuroim.2006.09.016

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  31 in total

Review 1.  Immune suppression in cancer: effects on immune cells, mechanisms and future therapeutic intervention.

Authors:  Theresa L Whiteside
Journal:  Semin Cancer Biol       Date:  2005-09-08       Impact factor: 15.707

Review 2.  ZAP-70 in B cell malignancies.

Authors:  Jenny Orchard; Rachel Ibbotson; Giles Best; Anton Parker; David Oscier
Journal:  Leuk Lymphoma       Date:  2005-12

Review 3.  The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target.

Authors:  C J Wikstrand; C J Reist; G E Archer; M R Zalutsky; D D Bigner
Journal:  J Neurovirol       Date:  1998-04       Impact factor: 2.643

4.  Differential selectivity of CIITA promoter activation by IFN-gamma and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-alpha.

Authors:  K M Nikcevich; J F Piskurich; R P Hellendall; Y Wang; J P Ting
Journal:  J Neuroimmunol       Date:  1999-10-29       Impact factor: 3.478

Review 5.  Gene therapy for malignant glioma: current clinical status.

Authors:  Kalevi J Pulkkanen; Seppo Yla-Herttuala
Journal:  Mol Ther       Date:  2005-10       Impact factor: 11.454

6.  Influence of in vivo growth on human glioma cell line gene expression: convergent profiles under orthotopic conditions.

Authors:  Kevin Camphausen; Benjamin Purow; Mary Sproull; Tamalee Scott; Tomoko Ozawa; Dennis F Deen; Philip J Tofilon
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-31       Impact factor: 11.205

7.  Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

Authors:  Ingo K Mellinghoff; Maria Y Wang; Igor Vivanco; Daphne A Haas-Kogan; Shaojun Zhu; Ederlyn Q Dia; Kan V Lu; Koji Yoshimoto; Julie H Y Huang; Dennis J Chute; Bridget L Riggs; Steve Horvath; Linda M Liau; Webster K Cavenee; P Nagesh Rao; Rameen Beroukhim; Timothy C Peck; Jeffrey C Lee; William R Sellers; David Stokoe; Michael Prados; Timothy F Cloughesy; Charles L Sawyers; Paul S Mischel
Journal:  N Engl J Med       Date:  2005-11-10       Impact factor: 91.245

8.  Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme.

Authors:  Yu Liang; Maximilian Diehn; Nathan Watson; Andrew W Bollen; Ken D Aldape; M Kelly Nicholas; Kathleen R Lamborn; Mitchel S Berger; David Botstein; Patrick O Brown; Mark A Israel
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-12       Impact factor: 11.205

9.  Gene-expression patterns predict phenotypes of immune-mediated thrombosis.

Authors:  Anil Potti; Andrea Bild; Holly K Dressman; Deborah A Lewis; Joseph R Nevins; Thomas L Ortel
Journal:  Blood       Date:  2005-11-01       Impact factor: 22.113

10.  Glioblastoma patients exhibit circulating tumor-specific CD8+ T cells.

Authors:  Jie Tang; Phyllis Flomenberg; Larry Harshyne; Lawrence Kenyon; David W Andrews
Journal:  Clin Cancer Res       Date:  2005-07-15       Impact factor: 12.531
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  3 in total

1.  Combination radiotherapy in an orthotopic mouse brain tumor model.

Authors:  Tamalee R Kramp; Kevin Camphausen
Journal:  J Vis Exp       Date:  2012-03-06       Impact factor: 1.355

Review 2.  Mouse models of glioblastoma for the evaluation of novel therapeutic strategies.

Authors:  Alexander F Haddad; Jacob S Young; Dominic Amara; Mitchel S Berger; David R Raleigh; Manish K Aghi; Nicholas A Butowski
Journal:  Neurooncol Adv       Date:  2021-07-26

3.  Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells.

Authors:  Laura M Epple; Rebecca D Dodd; Andrea L Merz; Anjelika M Dechkovskaia; Matthew Herring; Benjamin A Winston; Alex M Lencioni; Rae L Russell; Helen Madsen; Meheret Nega; Nathaniel L Dusto; Jason White; Darell D Bigner; Christopher V Nicchitta; Natalie J Serkova; Michael W Graner
Journal:  PLoS One       Date:  2013-08-15       Impact factor: 3.240
  3 in total

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