Literature DB >> 17136892

A new antifungal macrolide, eushearilide, isolated from Eupenicillium shearii.

Tomoo Hosoe1, Kazutaka Fukushima, Kayoko Takizawa, Takeshi Itabashi, Nobuo Kawahara, Valerio Vidotto, Ken-Ichi Kawai.   

Abstract

In screening for antifungal substances, a new macrolide, eushearilide (1), was isolated from Eupenicillium shearii IFM54447. The structure of 1 was established to be 24-membered macrolide having a non-conjugated diene and a choline phosphate ester moetiy on the basis of detailed investigation of NMR, UV, IR and MS spectral data. Compound 1 showed antifungal activity against various fungi and yeasts, including human pathogens Aspergillus fumigatus, Trichophyton spp. and Candida spp.

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Year:  2006        PMID： 17136892     DOI： 10.1038/ja.2006.80

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

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3.  Enantioselective total synthesis of naturally occurring eushearilide and evaluation of its antifungal activity.

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Journal:  J Antibiot (Tokyo)       Date:  2016-01-27       Impact factor: 2.649

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7.  CFTR Modulators Dampen Aspergillus-Induced Reactive Oxygen Species Production by Cystic Fibrosis Phagocytes.

Authors:  Alexander J Currie; Ellen T Main; Heather M Wilson; Darius Armstrong-James; Adilia Warris
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8.  Total Synthesis and Antimicrobial Evaluation of 23-Demethyleushearilide and Extensive Antimicrobial Evaluation of All Synthetic Stereoisomers of (16Z,20E)-Eushearilide and (16E,20E)-Eushearilide.

Authors:  Takayuki Tonoi; Takehiko Inohana; Teruyuki Sato; Yuuki Noda; Miyuki Ikeda; Miku Akutsu; Takatsugu Murata; Yutaro Maekawa; Anna Tanaka; Rio Seki; Misako Ohkusu; Katsuhiko Kamei; Naruhiko Ishiwada; Isamu Shiina
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  8 in total

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