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Literature DB >> 17136680

The structure and function of cartilage proteoglycans.

Abstract

Cartilage contains a variety of proteoglycans that are essential for its normal function. These include aggrecan, decorin, biglycan, fibromodulin and lumican. Each proteoglycan serves several functions that are determined by both its core protein and its glycosaminoglycan chains. This review discusses the structure/function relationships of the cartilage proteoglycans, and the manner in which perturbations in proteoglycan structure or abundance can adversely affect tissue function.

Entities: Disease Gene

Mesh：

Substances：
Aggrecans
Proteoglycans

Year: 2006 PMID： 17136680 DOI： 10.22203/ecm.v012a11

Source DB: PubMed Journal: Eur Cell Mater ISSN： 1473-2262 Impact factor: 3.942

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Cited

98 in total

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3. Tissue engineering by molecular disassembly and reassembly: biomimetic retention of mechanically functional aggrecan in hydrogel.

Authors: EunHee Han; Lissette M Wilensky; Barbara L Schumacher; Albert C Chen; Koichi Masuda; Robert L Sah
Journal: Tissue Eng Part C Methods Date: 2010-06-09 Impact factor: 3.056

The structure and function of cartilage proteoglycans.

Review 1. Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis.

2. Distribution and processing of a disintegrin and metalloproteinase with thrombospondin motifs-4, aggrecan, versican, and hyaluronan in equine digital laminae.

3. Tissue engineering by molecular disassembly and reassembly: biomimetic retention of mechanically functional aggrecan in hydrogel.

4. Single-molecule force spectroscopy of cartilage aggrecan self-adhesion.

5. Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways.

6. Potential role of cathepsin K in the pathophysiology of mucopolysaccharidoses.

Review 7. MR imaging of articular cartilage physiology.

Review 8. Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials.

9. Immunolocalization of proteoglycans in Meckel's cartilage of the rat.

10. The matricellular functions of small leucine-rich proteoglycans (SLRPs).