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Literature DB >> 17136390

PTEN targeting: the search for novel insulin sensitisers provides new insight into obesity research.

Francesco Beguinot¹.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2007 PMID： 17136390 DOI： 10.1007/s00125-006-0547-2

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

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18 in total

1. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Authors: D D Sarbassov; David A Guertin; Siraj M Ali; David M Sabatini
Journal: Science Date: 2005-02-18 Impact factor: 47.728

2. Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.

Authors: Mark W Sleeman; Katherine E Wortley; Ka-Man V Lai; Lori C Gowen; Jennifer Kintner; William O Kline; Karen Garcia; Trevor N Stitt; George D Yancopoulos; Stanley J Wiegand; David J Glass
Journal: Nat Med Date: 2005-01-16 Impact factor: 53.440

3. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.

Authors: D Liaw; D J Marsh; J Li; P L Dahia; S I Wang; Z Zheng; S Bose; K M Call; H C Tsou; M Peacocke; C Eng; R Parsons
Journal: Nat Genet Date: 1997-05 Impact factor: 38.330

Review 4. The PI3K-PDK1 connection: more than just a road to PKB.

Authors: B Vanhaesebroeck; D R Alessi
Journal: Biochem J Date: 2000-03-15 Impact factor: 3.857

5. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue.

Authors: Christine Kurlawalla-Martinez; Bangyan Stiles; Ying Wang; Sherin U Devaskar; Barbara B Kahn; Hong Wu
Journal: Mol Cell Biol Date: 2005-03 Impact factor: 4.272

6. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas.

Authors: Yasuo Horie; Akira Suzuki; Ei Kataoka; Takehiko Sasaki; Koichi Hamada; Junko Sasaki; Katsunori Mizuno; Go Hasegawa; Hiroyuki Kishimoto; Masahiro Iizuka; Makoto Naito; Katsuhiko Enomoto; Sumio Watanabe; Tak Wah Mak; Toru Nakano
Journal: J Clin Invest Date: 2004-06 Impact factor: 14.808

PTEN targeting: the search for novel insulin sensitisers provides new insight into obesity research.

1. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

2. Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.

3. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.

Review 4. The PI3K-PDK1 connection: more than just a road to PKB.

5. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue.

6. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas.

7. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.

Review 8. PDK1, the master regulator of AGC kinase signal transduction.

9. Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats.

10. Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity.