BACKGROUND: Quinine remains the treatment of choice in hospitalized malaria cases; however, adverse reactions and the long treatment duration of 7 days often hamper its adequate use. Shortening the treatment by adding sulfadoxine/pyrimethamine may enhance compliance and reduce side effects. We aimed to assess the efficacy of a 3-day course of quinine plus a single dose of sulfadoxine/pyrimethamine for the treatment of non-severe hospitalized malaria cases in Lambaréné, Gabon. METHODS: Fifty children aged between 2 and 7 years received quinine dihydrochloride (12 mg/kg every 12 hours for 72 hours), and then a single dose of oral SP (500 mg/25 mg tablet) was given according to weight category. The children were hospitalized for the duration of the treatment and until two consecutive blood smears were negative for malaria parasites. The follow-up period lasted 28 days. RESULTS: Parasites were cleared after 66 hours (SD: 15 hours) and the fever after 46 hours (SD: 24 hours). All patients evaluable by day 28 were negative for malaria parasites (100% efficacy rate, 95% CI: 0.92-1). Only two patients out of 49 had gametocytemia on days 7 and 14. There was no adverse event probably or possibly attributable to the study drugs. CONCLUSIONS: A very high efficacy can be reached using a 3-day course of quinine plus a single dose of sulfadoxine/pyrimethamine for the treatment of non-severe hospitalized malaria cases in our study area.
BACKGROUND:Quinine remains the treatment of choice in hospitalized malaria cases; however, adverse reactions and the long treatment duration of 7 days often hamper its adequate use. Shortening the treatment by adding sulfadoxine/pyrimethamine may enhance compliance and reduce side effects. We aimed to assess the efficacy of a 3-day course of quinine plus a single dose of sulfadoxine/pyrimethamine for the treatment of non-severe hospitalized malaria cases in Lambaréné, Gabon. METHODS: Fifty children aged between 2 and 7 years received quinine dihydrochloride (12 mg/kg every 12 hours for 72 hours), and then a single dose of oral SP (500 mg/25 mg tablet) was given according to weight category. The children were hospitalized for the duration of the treatment and until two consecutive blood smears were negative for malaria parasites. The follow-up period lasted 28 days. RESULTS: Parasites were cleared after 66 hours (SD: 15 hours) and the fever after 46 hours (SD: 24 hours). All patients evaluable by day 28 were negative for malaria parasites (100% efficacy rate, 95% CI: 0.92-1). Only two patients out of 49 had gametocytemia on days 7 and 14. There was no adverse event probably or possibly attributable to the study drugs. CONCLUSIONS: A very high efficacy can be reached using a 3-day course of quinine plus a single dose of sulfadoxine/pyrimethamine for the treatment of non-severe hospitalized malaria cases in our study area.
Authors: M Adjuik; P Agnamey; A Babiker; S Borrmann; P Brasseur; M Cisse; F Cobelens; S Diallo; J F Faucher; P Garner; S Gikunda; P G Kremsner; S Krishna; B Lell; M Loolpapit; P B Matsiegui; M A Missinou; J Mwanza; F Ntoumi; P Olliaro; P Osimbo; P Rezbach; E Some; W R J Taylor Journal: Lancet Date: 2002-04-20 Impact factor: 79.321
Authors: A P Hall; E B Doberstyn; C Karnchanachetanee; S Samransamruajkit; B Laixuthai; E J Pearlman; R M Lampe; C F Miller; P Phintuyothin Journal: Br Med J Date: 1977-06-25
Authors: P G Kremsner; P Radloff; W Metzger; E Wildling; B Mordmüller; J Philipps; L Jenne; M Nkeyi; J Prada; U Bienzle Journal: Antimicrob Agents Chemother Date: 1995-07 Impact factor: 5.191
Authors: Elisabeth Hugosson; Donath Tarimo; Marita Troye-Blomberg; Scott M Montgomery; Zul Premji; Anders Björkman Journal: Am J Trop Med Hyg Date: 2003-10 Impact factor: 2.345
Authors: Marielle K Bouyou-Akotet; Michael Ramharter; Edgard Brice Ngoungou; Modeste Mabika Mamfoumbi; Mireille Pemba Mihindou; Michel A Missinou; Florian Kurth; Sabine Bélard; Selidji T Agnandji; Saadou Issifou; János L Heidecker; Sonja Trapp; Peter G Kremsner; Maryvonne Kombila Journal: Wien Klin Wochenschr Date: 2010-03 Impact factor: 1.704