| Literature DB >> 17136124 |
M A Salih1, M E Ibrahim, J M Blackwell, E N Miller, E A G Khalil, A M ElHassan, A M Musa, H S Mohamed.
Abstract
Post-kala-azar dermal leishmanaisis (PKDL) in Sudan is associated with elevated interferon-gamma (IFN-gamma). To study interferon-gamma pathways in PKDL, we genotyped 80 trios from the Masalit ethnic group for polymorphisms at -470 ins/delTT, -270T/C, -56T/C and +95T/C in IFNGR1 and at -179G/A and +874T/A in IFNG. No associations occurred at IFNG. Global association with haplotypes comprising all four markers at IFNGR1 (chi(2)(10df)=21.97, P=0.015) was observed, associated with a significant (chi(2)(1df)=4.54, P=0.033) bias in transmission of the haplotype insTT T T T and less (chi(2)(1df)=5.59, P=0.018) than expected transmission of insTT C C C. When compared with data on malaria associations from Gambia, the results suggest a complex pattern of haplotypic variation at the IFNGR1 promoter locus associated with different infectious disease in African populations that reflect the complex roles of IFN-gamma in parasite killing versus inflammation and pathogenesis.Entities:
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Year: 2006 PMID： 17136124 PMCID： PMC2330095 DOI： 10.1038/sj.gene.6364353
Source DB: PubMed Journal: Genes Immun ISSN： 1466-4879 Impact factor: 2.676