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Literature DB >> 1713612

Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study.

S N Schiffmann¹, O Jacobs, J J Vanderhaeghen.

Abstract

RDC8 has been recently cloned and characterized as an adenosine A2 receptor. This receptor is expressed exclusively by medium-sized neurons of the striatum as demonstrated by in situ hybridization. We have now studied the relationship of this receptor with three major components of the rat caudate-putamen: enkephalin, substance P, and choline acetyltransferase. Our results demonstrate that the adenosine A2 receptor is expressed exclusively by the enkephalinergic striatal subpopulation but not by the substance P-containing or cholinergic neurons.

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Year: 1991 PMID： 1713612 DOI： 10.1111/j.1471-4159.1991.tb08257.x

Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372

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Cited

122 in total

1. A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice.

Authors: J F Chen; Z Huang; J Ma; J Zhu; R Moratalla; D Standaert; M A Moskowitz; J S Fink; M A Schwarzschild
Journal: J Neurosci Date: 1999-11-01 Impact factor: 6.167

2. Functional uncoupling of adenosine A(2A) receptors and reduced responseto caffeine in mice lacking dopamine D2 receptors.

Authors: N R Zahniser; J K Simosky; R D Mayfield; C A Negri; T Hanania; G A Larson; M A Kelly; D K Grandy; M Rubinstein; M J Low; B B Fredholm
Journal: J Neurosci Date: 2000-08-15 Impact factor: 6.167

3. Development of a unilaterally-lesioned 6-OHDA mouse model of Parkinson's disease.

Authors: Sherri L Thiele; Ruth Warre; Joanne E Nash
Journal: J Vis Exp Date: 2012-02-14 Impact factor: 1.355

Review 4. Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders.

Authors: K Fuxe; D Marcellino; D O Borroto-Escuela; M Guescini; V Fernández-Dueñas; S Tanganelli; A Rivera; F Ciruela; L F Agnati
Journal: CNS Neurosci Ther Date: 2010-03-16 Impact factor: 5.243

Review 5. Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders.

Authors: Sergi Ferré
Journal: Psychopharmacology (Berl) Date: 2016-01-20 Impact factor: 4.530

6. Functional histamine H₃ and adenosine A_2A receptor heteromers in recombinant cells and rat striatum.

Authors: Ricardo Márquez-Gómez; Meridith T Robins; Citlaly Gutiérrez-Rodelo; Juan-Manuel Arias; Jesús-Alberto Olivares-Reyes; Richard M van Rijn; José-Antonio Arias-Montaño
Journal: Pharmacol Res Date: 2017-12-05 Impact factor: 7.658

7. Adenosine A2 receptor regulation of apomorphine-induced turning in rats with unilateral striatal dopamine denervation.

Authors: S V Vellucci; D J Sirinathsinghji; P J Richardson
Journal: Psychopharmacology (Berl) Date: 1993 Impact factor: 4.530

Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study.

1. A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice.

2. Functional uncoupling of adenosine A(2A) receptors and reduced responseto caffeine in mice lacking dopamine D2 receptors.

3. Development of a unilaterally-lesioned 6-OHDA mouse model of Parkinson's disease.

Review 4. Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders.

Review 5. Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders.

6. Functional histamine H₃ and adenosine A_2A receptor heteromers in recombinant cells and rat striatum.

7. Adenosine A2 receptor regulation of apomorphine-induced turning in rats with unilateral striatal dopamine denervation.

Review 8. Role of adenosine A_2A receptors in motor control: relevance to Parkinson's disease and dyskinesia.

9. Adenosine receptor-mediated modulation of acetylcholine release from rat striatal synaptosomes.

Review 10. Release and actions of adenosine in the central nervous system.

Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study.

1. A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice.

2. Functional uncoupling of adenosine A(2A) receptors and reduced responseto caffeine in mice lacking dopamine D2 receptors.

3. Development of a unilaterally-lesioned 6-OHDA mouse model of Parkinson's disease.

Review 4. Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders.

Review 5. Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders.

6. Functional histamine H3 and adenosine A2A receptor heteromers in recombinant cells and rat striatum.

7. Adenosine A2 receptor regulation of apomorphine-induced turning in rats with unilateral striatal dopamine denervation.

Review 8. Role of adenosine A2A receptors in motor control: relevance to Parkinson's disease and dyskinesia.

9. Adenosine receptor-mediated modulation of acetylcholine release from rat striatal synaptosomes.

Review 10. Release and actions of adenosine in the central nervous system.

6. Functional histamine H₃ and adenosine A_2A receptor heteromers in recombinant cells and rat striatum.

Review 8. Role of adenosine A_2A receptors in motor control: relevance to Parkinson's disease and dyskinesia.