BACKGROUND: The long-term risks of stroke associated with hypothyroidism and hyperthyroidism is unknown. We evaluated the long-term risk of stroke with hypothyroidism and hyperthyroidism compared with euthyroid status. MATERIAL/ METHODS: We used the 20-year follow-up data for adults aged 25 to 74 years who participated in the First National Health and Nutrition Examination Survey Follow-up Study. Hypothyroidism or hyperthyroidism was diagnosed by free thyroxine index measurements at baseline evaluation and incident events were determined from hospital records and death certificates during follow-up. Relative risk (RR) of stroke, ischemic stroke, and intracerebral hemorrhage for each category of thyroid function were determined by Cox proportional hazards analysis after adjustment for potential confounding variables. RESULTS: A total of 5,269 participants (mean age 48+/-14 years; 2,379 men) were evaluated. Hypothyroidism and hyperthyroidism were diagnosed in 493 (9.4%) and 34 (0.7%) participants, respectively. After adjustment for covariates, a significantly higher RR for all strokes and for ischemic stroke was observed in participants with hypothyroidism (RR 1.6; 95% confidence interval (CI), 1.0-2.6 and RR 1.6, 95% CI, 1.0-2.7, respectively). Hyperthyroidism was not associated with an increased risk for stroke. CONCLUSIONS: An increased risk for stroke (particularly ischemic stroke) was observed in patients with hypothyroidism.
BACKGROUND: The long-term risks of stroke associated with hypothyroidism and hyperthyroidism is unknown. We evaluated the long-term risk of stroke with hypothyroidism and hyperthyroidism compared with euthyroid status. MATERIAL/ METHODS: We used the 20-year follow-up data for adults aged 25 to 74 years who participated in the First National Health and Nutrition Examination Survey Follow-up Study. Hypothyroidism or hyperthyroidism was diagnosed by freethyroxine index measurements at baseline evaluation and incident events were determined from hospital records and death certificates during follow-up. Relative risk (RR) of stroke, ischemic stroke, and intracerebral hemorrhage for each category of thyroid function were determined by Cox proportional hazards analysis after adjustment for potential confounding variables. RESULTS: A total of 5,269 participants (mean age 48+/-14 years; 2,379 men) were evaluated. Hypothyroidism and hyperthyroidism were diagnosed in 493 (9.4%) and 34 (0.7%) participants, respectively. After adjustment for covariates, a significantly higher RR for all strokes and for ischemic stroke was observed in participants with hypothyroidism (RR 1.6; 95% confidence interval (CI), 1.0-2.6 and RR 1.6, 95% CI, 1.0-2.7, respectively). Hyperthyroidism was not associated with an increased risk for stroke. CONCLUSIONS: An increased risk for stroke (particularly ischemic stroke) was observed in patients with hypothyroidism.
Authors: Yu Ning; Yun J Cheng; Li J Liu; Jaskanwal D S Sara; Zhi Y Cao; Wei P Zheng; Tian S Zhang; Hui J Han; Zhen Y Yang; Yi Zhang; Fei L Wang; Rui Y Pan; Jie L Huang; Ling L Wu; Ming Zhang; Yong X Wei Journal: BMC Med Date: 2017-02-02 Impact factor: 8.775
Authors: Julia Six-Merker; Christa Meisinger; Carolin Jourdan; Margit Heier; Hans Hauner; Annette Peters; Jakob Linseisen Journal: PLoS One Date: 2016-05-18 Impact factor: 3.240