BACKGROUND: Erythroderma can be caused by inflammatory dermatoses or cutaneous T-cell lymphoma. Even if chemokines and their receptors are involved in the skin-selective lymphocyte recruitment, their role in inflammatory erythroderma is yet unclear. OBJECTIVE: To evaluate the chemokine release (TARC, MDC, IP-10) and to define the expression pattern of Th1- (CCR5, CXCR3) and Th2-related (CCR4) chemokine receptors in inflammatory erythroderma and Sézary syndrome (SS). MATERIALS AND METHODS: Flow cytometry has been carried out on both circulating and skin-infiltrating T lymphocytes; serum chemokine levels have been evaluated using ELISA techniques. RESULTS: CCR4, CCR5 and CXCR3 were expressed on about 40% of peripheral blood lymphocytes and on the majority of skin-infiltrating lymphocytes in the inflammatory erythroderma patients, whereas the leukemic CD4+CD26- subpopulation in SS was characterized by a high CCR4 expression without a concurrent increase in CCR5 or CXCR3. TARC, MDC and IP-10 serum levels were significantly increased in both erythrodermic and SS patients. CONCLUSIONS: Our results confirm that SS is a Th2 disorder with a selective expression of CCR4, whereas inflammatory erythroderma shares an overexpression of both Th1- and Th2-related chemokine receptors, suggesting an activation of different pathways driving reactive lymphocytes to the skin. Copyright (c) 2006 S. Karger AG, Basel.
BACKGROUND:Erythroderma can be caused by inflammatory dermatoses or cutaneous T-cell lymphoma. Even if chemokines and their receptors are involved in the skin-selective lymphocyte recruitment, their role in inflammatory erythroderma is yet unclear. OBJECTIVE: To evaluate the chemokine release (TARC, MDC, IP-10) and to define the expression pattern of Th1- (CCR5, CXCR3) and Th2-related (CCR4) chemokine receptors in inflammatory erythroderma and Sézary syndrome (SS). MATERIALS AND METHODS: Flow cytometry has been carried out on both circulating and skin-infiltrating T lymphocytes; serum chemokine levels have been evaluated using ELISA techniques. RESULTS:CCR4, CCR5 and CXCR3 were expressed on about 40% of peripheral blood lymphocytes and on the majority of skin-infiltrating lymphocytes in the inflammatory erythrodermapatients, whereas the leukemic CD4+CD26- subpopulation in SS was characterized by a high CCR4 expression without a concurrent increase in CCR5 or CXCR3. TARC, MDC and IP-10 serum levels were significantly increased in both erythrodermic and SS patients. CONCLUSIONS: Our results confirm that SS is a Th2 disorder with a selective expression of CCR4, whereas inflammatory erythroderma shares an overexpression of both Th1- and Th2-related chemokine receptors, suggesting an activation of different pathways driving reactive lymphocytes to the skin. Copyright (c) 2006 S. Karger AG, Basel.
Authors: Rosita Rigoni; Elena Fontana; Kerry Dobbs; Veronica Marrella; Valentina Taverniti; Virginia Maina; Amanda Facoetti; Giovanna D'Amico; Waleed Al-Herz; Mario Ernesto Cruz-Munoz; Catharina Schuetz; Andrew R Gennery; Elizabeth K Garabedian; Silvia Giliani; Deborah Draper; Ghassan Dbaibo; Raif S Geha; Isabelle Meyts; Thomas Tousseyn; Benedicte Neven; Despina Moshous; Alain Fischer; Ansgar Schulz; Andrea Finocchi; Douglas B Kuhns; Danielle L Fink; Michail S Lionakis; Muthulekha Swamydas; Simone Guglielmetti; Julie Alejo; Ian A Myles; Stefania Pittaluga; Luigi D Notarangelo; Anna Villa; Barbara Cassani Journal: J Allergy Clin Immunol Date: 2020-04-18 Impact factor: 10.793
Authors: Keertan Dheda; Richard N Van-Zyl Smit; Leonardo A Sechi; Motasim Badri; Richard Meldau; Gregory Symons; Hoosein Khalfey; Igshaan Carr; Alice Maredza; Rodney Dawson; Helen Wainright; Andrew Whitelaw; Eric D Bateman; Alimuddin Zumla Journal: PLoS One Date: 2009-03-11 Impact factor: 3.240