BACKGROUND: Receptors for vitamin D have been found in various tissues, including the vascular endothelium. The role of vitamin D in the haemostatic process is uncertain, but in vitro studies may indicate a pro-fibrinolytic effect. METHODS: Two hundred and six subjects (105 males) were included in the study. The relations between indices of calcium metabolism and haemostatic factors [tissue plasminogen activator antigen (tPA Ag), plasminogen activator inhibitor 1 (PAI-1), prothrombin fragment 1+2, activated factor VII and total factor VII coagulant activity] and high-sensitivity C-reactive protein (HS-CRP) were examined. RESULTS: There were significant and negative correlations between serum 25(OH) vitamin D and PAI-1 and tPA Ag, and between serum 1,25(OH)2 vitamin D and tPA Ag and HS-CRP. In a multiple linear regression model with age, gender, body mass index and smoking status as covariables, only the relation between 25(OH) vitamin D and tPA Ag was significant. There were no significant relations between any of the haemostatic factors tested and serum parathyroid hormone. CONCLUSION: It appears that the serum level of vitamin D is related to fibrinolytic activity and to the integrity of the vascular endothelium, but the clinical importance of this observation remains to be determined. 2007 S. Karger AG, Basel
BACKGROUND: Receptors for vitamin D have been found in various tissues, including the vascular endothelium. The role of vitamin D in the haemostatic process is uncertain, but in vitro studies may indicate a pro-fibrinolytic effect. METHODS: Two hundred and six subjects (105 males) were included in the study. The relations between indices of calcium metabolism and haemostatic factors [tissue plasminogen activator antigen (tPA Ag), plasminogen activator inhibitor 1 (PAI-1), prothrombin fragment 1+2, activated factor VII and total factor VII coagulant activity] and high-sensitivity C-reactive protein (HS-CRP) were examined. RESULTS: There were significant and negative correlations between serum 25(OH) vitamin D and PAI-1 and tPA Ag, and between serum 1,25(OH)2 vitamin D and tPA Ag and HS-CRP. In a multiple linear regression model with age, gender, body mass index and smoking status as covariables, only the relation between 25(OH) vitamin D and tPA Ag was significant. There were no significant relations between any of the haemostatic factors tested and serum parathyroid hormone. CONCLUSION: It appears that the serum level of vitamin D is related to fibrinolytic activity and to the integrity of the vascular endothelium, but the clinical importance of this observation remains to be determined. 2007 S. Karger AG, Basel
Authors: Marc Blondon; Rebecca J Rodabough; Nicole Budrys; Karen C Johnson; Jeffrey S Berger; James M Shikany; Azad Raiesdana; Susan R Heckbert; JoAnn E Manson; Andrea Z LaCroix; David Siscovick; Bryan Kestenbaum; Nicholas L Smith; Ian H de Boer Journal: Thromb Haemost Date: 2015-02-12 Impact factor: 5.249
Authors: Marc Blondon; Mary Cushman; Nancy Jenny; Erin D Michos; Nicholas L Smith; Bryan Kestenbaum; Ian H de Boer Journal: J Clin Endocrinol Metab Date: 2016-03-29 Impact factor: 5.958
Authors: Laura P B Elbers; Marije Wijnberge; Joost C M Meijers; Dennis C W Poland; Dees P M Brandjes; Eric Fliers; Victor E A Gerdes Journal: Endocr Connect Date: 2018-01-09 Impact factor: 3.335