Literature DB >> 17135324

Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication.

Chungwon Chung1, Wonhee Lee, John T Loffredo, Benjamin Burwitz, Thomas C Friedrich, Juan Pablo Giraldo Vela, Gnankang Napoe, Eva G Rakasz, Nancy A Wilson, David B Allison, David I Watkins.   

Abstract

Current assays of CD8+ T-lymphocyte function measure cytokine production rather than the ability of these lymphocytes to suppress viral replication. Here we show that CD8+ T-cell clones recognizing the same epitope vary enormously in the ability to suppress simian immunodeficiency virus SIVmac239 replication in an in vitro suppression assay. However, all Nef(165-173)IW9- and Vif(66-73)HW8-specific clones from elite controllers effectively suppressed SIV replication. Interestingly, in vitro suppression efficacy was not always associated with the ability to produce gamma interferon, tumor necrosis factor alpha, or interleukin-2.

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Year:  2006        PMID： 17135324      PMCID： PMC1797528          DOI： 10.1128/JVI.01780-06

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  56 in total

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4.  Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes.

Authors:  M E Klotman; S Kim; A Buchbinder; A DeRossi; D Baltimore; F Wong-Staal
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

5.  Impacts of avidity and specificity on the antiviral efficiency of HIV-1-specific CTL.

Authors:  Otto O Yang; Phuong T Nguyen Sarkis; Alicja Trocha; Spyros A Kalams; R Paul Johnson; Bruce D Walker
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6.  Identification of seventeen new simian immunodeficiency virus-derived CD8+ T cell epitopes restricted by the high frequency molecule, Mamu-A*02, and potential escape from CTL recognition.

Authors:  John T Loffredo; John Sidney; Christina Wojewoda; Elizabeth Dodds; Matthew R Reynolds; Gnankang Napoé; Bianca R Mothé; David H O'Connor; Nancy A Wilson; David I Watkins; Alessandro Sette
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Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

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  23 in total

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3.  The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages.

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4.  Recognition of escape variants in ELISPOT does not always predict CD8+ T-cell recognition of simian immunodeficiency virus-infected cells expressing the same variant sequences.

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7.  Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic.

Authors:  Lara Vojnov; Jason S Reed; Kim L Weisgrau; Eva G Rakasz; John T Loffredo; Shari M Piaskowski; Jonah B Sacha; Holly L Kolar; Nancy A Wilson; R Paul Johnson; David I Watkins
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9.  The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers.

Authors:  Juan P Giraldo-Vela; Richard Rudersdorf; Chungwon Chung; Ying Qi; Lyle T Wallace; Benjamin Bimber; Gretta J Borchardt; Debra L Fisk; Chrystal E Glidden; John T Loffredo; Shari M Piaskowski; Jessica R Furlott; Juan P Morales-Martinez; Nancy A Wilson; William M Rehrauer; Jeffrey D Lifson; Mary Carrington; David I Watkins
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10.  Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239{Delta}nef-vaccinated macaques suppress SIVmac239 replication ex vivo.

Authors:  Justin M Greene; Jennifer J Lhost; Benjamin J Burwitz; Melisa L Budde; Caitlin E Macnair; Madelyn K Weiker; Emma Gostick; Thomas C Friedrich; Karl W Broman; David A Price; Shelby L O'Connor; David H O'Connor
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