| Literature DB >> 17134813 |
Cong Luo1, Yongliang Zhu, Tiejun Jiang, Xiaoyong Lu, Wo Zhang, Qifeng Jing, Jia Li, Linrong Pang, Kangjie Chen, Fuming Qiu, Xiuyan Yu, Jiahui Yang, Jian Huang.
Abstract
Matrine, one of the main active components from the dry roots of Sophora flavescence, was known to induce apoptosis in a variety of tumor cells in vitro. However, the molecular mechanism of cell apoptosis induced by Matrine remains elusive. Here, we investigated the apoptosis in Matrine-treated human gastric cancer MKN45 cells. The results showed that Matrine could inhibit cell proliferation and induce apoptosis in a dose-dependent manner. Further immunoblots revealed that in Matrine-treated cells, caspase-3, -7 were activated and the pro-apoptotic molecules Bok, Bak, Bax, Puma, and Bim were also up-regulated. Our results suggested that Matrine induced gastric cancer MKN45 cells apoptosis via increasing pro-apoptotic molecules of Bcl-2 family.Entities:
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Year: 2006 PMID： 17134813 DOI： 10.1016/j.tox.2006.10.020
Source DB: PubMed Journal: Toxicology ISSN： 0300-483X Impact factor: 4.221