| Literature DB >> 17134795 |
N Guiso1, E Njamkepo, F Vié le Sage, F Zepp, C U Meyer, V Abitbol, N Clyti, S Chevallier.
Abstract
Humoral and cell-mediated immune responses (CMI) were evaluated in subjects 3 and 6 years after primary and booster vaccination with either three-component acellular (Pa) or whole-cell (Pw) vaccines. Low anti-pertussis toxin (PT) antibody levels confirmed the absence of pertussis disease, consistent with ongoing protection. Anti-pertactin (PRN) antibodies, remained at higher levels in Pa-vaccinated subjects. At year 6, CMI responses continued to be present and were higher in Pa-vaccinated than Pw-vaccinated subjects. Long-term protection with Pa vaccines can be expected to be at least as good as that provided by efficacious Pw vaccines.Entities:
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Year: 2006 PMID： 17134795 DOI： 10.1016/j.vaccine.2006.10.048
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641