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Literature DB >> 17134278

Nonenzymatic oligomerization of RNA by TNA templates.

Benjamin D Heuberger¹, Christopher Switzer.

Abstract

Cytosine TNA promotes nonenzymatic, template-directed oligomerization of complementary activated rGMP, leading to selective and efficient formation of RNA products. This process models "genetic takeover" of a pre-RNA by RNA. [reaction: see text]

Entities: Chemical

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Year: 2006 PMID： 17134278 DOI： 10.1021/ol062368s

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

7 in total

1. An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination.

Authors: Yueyao Wang; Yao Wang; Dongfan Song; Xin Sun; Zhe Li; Jia-Yu Chen; Hanyang Yu
Journal: Nat Chem Date: 2021-12-16 Impact factor: 24.427

2. Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers.

Authors: Jason P Schrum; Alonso Ricardo; Mathangi Krishnamurthy; J Craig Blain; Jack W Szostak
Journal: J Am Chem Soc Date: 2009-10-14 Impact factor: 15.419

Nonenzymatic oligomerization of RNA by TNA templates.

1. An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination.

2. Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers.

3. Synthesis and nonenzymatic template-directed polymerization of 2'-amino-2'-deoxythreose nucleotides.

4. pH-controlled DNA- and RNA-templated assembly of short oligomers.

5. Crystallographic observation of nonenzymatic RNA primer extension.

6. DNA-Templated N(Me)-Alkoxyamine Glycosylation.

7. Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization.