Literature DB >> 17134263

Vibralactone: a lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans.

Dong-Ze Liu1, Fei Wang, Tou-Gen Liao, Jian-Guo Tang, Wolfgang Steglich, Hua-Jie Zhu, Ji-Kai Liu.   

Abstract

The structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused beta-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 microg/mL. [structure: see text]

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Year:  2006        PMID： 17134263     DOI： 10.1021/ol062307u

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  21 in total

1.  Synthesis of (+/-)- and (-)-vibralactone and vibralactone C.

Authors:  Quan Zhou; Barry B Snider
Journal:  J Org Chem       Date:  2008-09-19       Impact factor: 4.354

2.  New bicyclic hemiacetals from the edible mushroom Ramaria madagascariensis.

Authors:  Dong-Ze Liu; Jian-Guo Li; Ming-Wei Zhang; Gang Liu
Journal:  J Antibiot (Tokyo)       Date:  2014-08-13       Impact factor: 2.649

3.  A Concise Total Synthesis of (±)-Vibralactone.

Authors:  Sepand K Nistanaki; Luke A Boralsky; Roy D Pan; Hosea M Nelson
Journal:  Angew Chem Int Ed Engl       Date:  2019-01-09       Impact factor: 15.336

4.  Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp.

Authors:  Xuan Hong; Xiaoqing Guan; Qiliang Lai; Dehua Yu; Zhongwei Chen; Xiaoteng Fu; Beibei Zhang; Changkun Chen; Zongze Shao; Jinmei Xia; Jiang-Jiang Qin; Weiyi Wang
Journal:  Appl Microbiol Biotechnol       Date:  2022-04-13       Impact factor: 4.813

5.  Lanostane triterpenoids from fruiting bodies of basidiomycete Stereum sp., structures and biological activities.

Authors:  Jian-Neng Yao; Lin Chen; Yang Tang; He-Ping Chen; Zhen-Zhu Zhao; Zheng-Hui Li; Tao Feng; Ji-Kai Liu
Journal:  J Antibiot (Tokyo)       Date:  2017-10-25       Impact factor: 2.649

6.  Synthesis of (+/-)-vibralactone.

Authors:  Quan Zhou; Barry B Snider
Journal:  Org Lett       Date:  2008-03-01       Impact factor: 6.005

7.  Structurally Diverse Alkaloids from the Seeds of Peganum harmala.

Authors:  Kai-Bo Wang; Da-Hong Li; Yu Bao; Fei Cao; Wen-Jing Wang; Clement Lin; Wen Bin; Jiao Bai; Yue-Hu Pei; Yong-Kui Jing; Danzhou Yang; Zhan-Lin Li; Hui-Ming Hua
Journal:  J Nat Prod       Date:  2017-01-27       Impact factor: 4.050

8.  The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents.

Authors:  Sonia A Tucci; Emma J Boyland; Jason Cg Halford
Journal:  Diabetes Metab Syndr Obes       Date:  2010-05-10       Impact factor: 3.168

9.  Structure-Based Optimization and Biological Evaluation of Pancreatic Lipase Inhibitors as Novel Potential Antiobesity Agents.

Authors:  Kun Wei; Gang-Qiang Wang; Xue Bai; Yan-Fen Niu; He-Ping Chen; Chun-Nan Wen; Zheng-Hui Li; Ze-Jun Dong; Zhi-Li Zuo; Wen-Yong Xiong; Ji-Kai Liu
Journal:  Nat Prod Bioprospect       Date:  2015-06-18

Review 10.  Inhibitors of pancreatic lipase: state of the art and clinical perspectives.

Authors:  Nitin A Lunagariya; Neeraj K Patel; Sneha C Jagtap; Kamlesh K Bhutani
Journal:  EXCLI J       Date:  2014-08-22       Impact factor: 4.068
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