PURPOSE OF REVIEW: Acute severe asthma is challenging to the clinician both in terms of recognition and appropriate treatment. About 30% of these episodes need admission to the medical intensive care unit with a mortality of 8%. Relapse rates vary from 7 to 15% depending on how well the patient is managed. The purpose of this review is to discuss recent advances in identification of risk factors, pathophysiology and management of acute severe asthma. RECENT FINDINGS: Although the exact mechanism for acute severe asthma is unclear, some that are implicated include inflammation, airway remodeling and downregulation of beta-receptors. None of the environmental factors have been clearly related to the development of near fatal attacks. Genetic polymorphisms have been associated with severe asthma. Lack of steroid responsiveness has been linked to severe asthma attacks. Chemokines and basement membrane changes characteristic of severe asthma are reported in a few studies. Lack of symptom perception in a certain group of patients with acute severe asthma leads to delayed interventions. Specific treatment modalities and ventilator management is reviewed. SUMMARY: Severe asthma is a phenotype of asthma with variable pathology and clinical presentation. Early recognition and timely intervention is needed to prevent significant mortality and morbidity.
PURPOSE OF REVIEW: Acute severe asthma is challenging to the clinician both in terms of recognition and appropriate treatment. About 30% of these episodes need admission to the medical intensive care unit with a mortality of 8%. Relapse rates vary from 7 to 15% depending on how well the patient is managed. The purpose of this review is to discuss recent advances in identification of risk factors, pathophysiology and management of acute severe asthma. RECENT FINDINGS: Although the exact mechanism for acute severe asthma is unclear, some that are implicated include inflammation, airway remodeling and downregulation of beta-receptors. None of the environmental factors have been clearly related to the development of near fatal attacks. Genetic polymorphisms have been associated with severe asthma. Lack of steroid responsiveness has been linked to severe asthma attacks. Chemokines and basement membrane changes characteristic of severe asthma are reported in a few studies. Lack of symptom perception in a certain group of patients with acute severe asthma leads to delayed interventions. Specific treatment modalities and ventilator management is reviewed. SUMMARY: Severe asthma is a phenotype of asthma with variable pathology and clinical presentation. Early recognition and timely intervention is needed to prevent significant mortality and morbidity.
Authors: Sangwoon Chung; Ji Y Kim; Min-Ae Song; Gye Y Park; Yong G Lee; Manjula Karpurapu; Joshua A Englert; Megan N Ballinger; Navjot Pabla; Hae Y Chung; John W Christman Journal: Allergy Date: 2018-11-05 Impact factor: 13.146
Authors: Shelley A Boeschoten; Corinne M P Buysse; Brenda C M de Winter; Joost van Rosmalen; Johan C de Jongste; Rogier C de Jonge; Sabien G J Heisterkamp; Job B van Woensel; Martin C J Kneyber; Annelies van Zwol; Annemie L M Boehmer; Matthijs de Hoog Journal: Eur J Pediatr Date: 2022-08-03 Impact factor: 3.860
Authors: Shelley A Boeschoten; Corinne M P Buysse; Peter J F M Merkus; Jacob M C van Wijngaarden; Sabien G J Heisterkamp; Johan C de Jongste; Joost van Rosmalen; Suzan C M Cochius-den Otter; Annemie L M Boehmer; Matthijs de Hoog Journal: Pediatr Pulmonol Date: 2018-04-10
Authors: Shelley A Boeschoten; Ruben S van der Crabben; Annemie L M Boehmer; Matthijs de Hoog; Corinne M P Buysse Journal: Case Rep Pediatr Date: 2019-09-09