Literature DB >> 17132932

HuR: post-transcriptional paths to malignancy.

Isabel López de Silanes1, Ashish Lal, Myriam Gorospe.   

Abstract

The RNA-binding protein HuR regulates the stability and translation of target mRNAs. While no HuR mutations have been found in cancer, a link between HuR and malignant transformation has been suggested in cancers of the breast, colon, lung and ovary. We describe a paradigm consistent with a central role of HuR in oncogenesis.

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Year:  2005        PMID： 17132932     DOI： 10.4161/rna.2.1.1552

Source DB:  PubMed          Journal:  RNA Biol        ISSN： 1547-6286            Impact factor:   4.652


  117 in total

Review 1.  Posttranscriptional regulation of cancer traits by HuR.

Authors:  Kotb Abdelmohsen; Myriam Gorospe
Journal:  Wiley Interdiscip Rev RNA       Date:  2010-05-06       Impact factor: 9.957

2.  The RNA-binding protein HuR opposes the repression of ERBB-2 gene expression by microRNA miR-331-3p in prostate cancer cells.

Authors:  Michael R Epis; Andrew Barker; Keith M Giles; Dianne J Beveridge; Peter J Leedman
Journal:  J Biol Chem       Date:  2011-10-04       Impact factor: 5.157

3.  Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis.

Authors:  Matthew M Gubin; Robert Calaluce; J Wade Davis; Joseph D Magee; Connie S Strouse; Daniel P Shaw; Lixin Ma; Ashley Brown; Timothy Hoffman; Tammy L Rold; Ulus Atasoy
Journal:  Cell Cycle       Date:  2010-08-17       Impact factor: 4.534

Review 4.  MicroRNA and AU-rich element regulation of prostaglandin synthesis.

Authors:  Ashleigh E Moore; Lisa E Young; Dan A Dixon
Journal:  Cancer Metastasis Rev       Date:  2011-12       Impact factor: 9.264

5.  Phosphorylation of HuR by Chk2 regulates SIRT1 expression.

Authors:  Kotb Abdelmohsen; Rudolf Pullmann; Ashish Lal; Hyeon Ho Kim; Stefanie Galban; Xiaoling Yang; Justin D Blethrow; Mark Walker; Jonathan Shubert; David A Gillespie; Henry Furneaux; Myriam Gorospe
Journal:  Mol Cell       Date:  2007-02-23       Impact factor: 17.970

6.  Global analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stability.

Authors:  Radharani Duttagupta; Bin Tian; Carol J Wilusz; Danny T Khounh; Patricia Soteropoulos; Ming Ouyang; Joseph P Dougherty; Stuart W Peltz
Journal:  Mol Cell Biol       Date:  2005-07       Impact factor: 4.272

7.  HuRrying colon cancer progression.

Authors:  Natalia A Ignatenko; Eugene W Gerner
Journal:  Cancer Biol Ther       Date:  2007-02-02       Impact factor: 4.742

Review 8.  microRNA-200b as a Switch for Inducible Adult Angiogenesis.

Authors:  Mithun Sinha; Subhadip Ghatak; Sashwati Roy; Chandan K Sen
Journal:  Antioxid Redox Signal       Date:  2015-05-10       Impact factor: 8.401

9.  Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis.

Authors:  Peng-Yuan Wang; Jaladanki N Rao; Tongtong Zou; Lan Liu; Lan Xiao; Ting-Xi Yu; Douglas J Turner; Myriam Gorospe; Jian-Ying Wang
Journal:  Biochem J       Date:  2010-02-24       Impact factor: 3.857

10.  Transcriptional control of human antigen R by bone morphogenetic protein.

Authors:  Selvi C Jeyaraj; Mamata Singh; Dina A Ayupova; Suman Govindaraju; Beth S Lee
Journal:  J Biol Chem       Date:  2009-12-14       Impact factor: 5.157
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