Literature DB >> 171323

Enhanced host defense mechanisms with levamisole in suckling rats.

G W Fischer, J K Podgore, J W Bass, J L Kelley, G Y Kobayaski.   

Abstract

Levamisole, a synthetically produced anthelminthic agent, was administered to suckling rats that were challenged with bacterial and viral pathogens. There was no in vitro antibacterial or antiviral effect of the drug. However, enhanced survival was demonstrated in those animals treated with levamisole and challenged with Staphylococcus aureus or herpes simplex virus. The mechanism for protection against the bacteria appears to be enhancement of the primary inflammatory response. The mechanism for protection against herpes simplex virus is not yet understood.

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Year:  1975        PMID： 171323     DOI： 10.1093/infdis/132.5.578

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  10 in total

1.  Inhibition of murine hepatitis virus infections by the immunomodulator 2,3,5,6,7,8-hexahydro-2-phenyl-8,8-dimethoxy-imidazo[1,2a]pyridine (PR-879-317A).

Authors:  R W Sidwell; J H Huffman; E W Call; R P Warren; L A Radov; R J Murray
Journal:  Antimicrob Agents Chemother       Date:  1987-07       Impact factor: 5.191

2.  The experimental and clinical use of immune-modulating drugs in the prophylaxis and treatment of infections.

Authors:  J Drews
Journal:  Infection       Date:  1985       Impact factor: 3.553

3.  Immunostimulation. Clinical and experimental perspectives.

Authors:  J Drews
Journal:  Klin Wochenschr       Date:  1984-03-15

4.  The experimental and clinical use of immune-modulating drugs in the prophylaxis and treatment of infections.

Authors:  J Drews
Journal:  Infection       Date:  1984 Mar-Apr       Impact factor: 3.553

5.  Chemotactic responses of various differentiational stages of neutrophils from human cord and adult blood.

Authors:  A Boner; B J Zeligs; J A Bellanti
Journal:  Infect Immun       Date:  1982-03       Impact factor: 3.441

6.  Enhanced killing of Candida albicans by cultured peritoneal exudate cells treated with SM-1213, a synthetic immunomodulator.

Authors:  C J Morrison; P Gordon; T Hashimoto
Journal:  Antimicrob Agents Chemother       Date:  1984-07       Impact factor: 5.191

7.  Effect of levamisole on experimental paracoccidioidomycosis in the Syrian hamster: immunologic and histopathologic correlation.

Authors:  M T Rezkallah-Iwasso; N G Mota; M C Gomes; M R Montenegro
Journal:  Mycopathologia       Date:  1984-02-15       Impact factor: 2.574

8.  Alveolar macrophage-lymphocyte rosette formation: failure of levamisole to alter activity.

Authors:  R L Ziprin; S R Fowler; D A Witzel
Journal:  Infect Immun       Date:  1977-05       Impact factor: 3.441

9.  Effect of pyran on latency after herpes simplex virus infections.

Authors:  P S Morahan; P F Cline; M C Breinig; B K Murray
Journal:  Antimicrob Agents Chemother       Date:  1979-04       Impact factor: 5.191

Review 10.  The general immunopharmacology of levamisole.

Authors:  G Renoux
Journal:  Drugs       Date:  1980-08       Impact factor: 9.546
  10 in total

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