Literature DB >> 17132211

The antioxidant role of pterostilbene in streptozotocin-nicotinamide-induced type 2 diabetes mellitus in Wistar rats.

M Amarnath Satheesh1, L Pari.   

Abstract

The antioxidant effect of pterostilbene on streptozotocin-nicotinamide-induced diabetic rats has been assessed. The activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reduced glutathione was significantly decreased in liver and kidney of diabetic animals when compared with normal control. There were significant improvements in these activities after treatment with pterostilbene at a dose of 40 mg kg(-1) for six weeks. The increased levels of lipid peroxidation measured as thiobarbituric acid reactive substances (TBARS) in liver and kidney of diabetic rats were also normalized by treatment with pterostilbene. Chronic treatment of pterostilbene remarkably reduced the pathological changes observed in liver and kidney of diabetic rats. These results indicated the antioxidant property of pterostilbene.

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Year:  2006        PMID： 17132211     DOI： 10.1211/jpp.58.11.0009

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  14 in total

1.  Comparative and combined effect of chlorogenic acid and tetrahydrocurcumin on antioxidant disparities in chemical induced experimental diabetes.

Authors:  Leelavinothan Pari; Krishnamoorthy Karthikesan; Venugopal P Menon
Journal:  Mol Cell Biochem       Date:  2010-03-26       Impact factor: 3.396

2.  Co-expression of VpROMT gene from Chinese wild Vitis pseudoreticulata with VpSTS in tobacco plants and its effects on the accumulation of pterostilbene.

Authors:  Y Xu; T F Xu; X C Zhao; Y Zou; Z Q Li; J Xiang; F J Li; Y J Wang
Journal:  Protoplasma       Date:  2011-10-29       Impact factor: 3.356

3.  Pterostilbene induces Nrf2/HO-1 and potentially regulates NF-κB and JNK-Akt/mTOR signaling in ischemic brain injury in neonatal rats.

Authors:  Qinghuang Zeng; Wenchang Lian; Guizhi Wang; Manping Qiu; Lingmu Lin; Renhe Zeng
Journal:  3 Biotech       Date:  2020-04-04       Impact factor: 2.406

4.  Pterostilbene reverses palmitic acid mediated insulin resistance in HepG2 cells by reducing oxidative stress and triglyceride accumulation.

Authors:  Sajad Ahmad Malik; Jhankar D Acharya; Neelay K Mehendale; Siddhesh S Kamat; Saroj S Ghaskadbi
Journal:  Free Radic Res       Date:  2019-07-10

Review 5.  A review of pterostilbene antioxidant activity and disease modification.

Authors:  Denise McCormack; David McFadden
Journal:  Oxid Med Cell Longev       Date:  2013-04-04       Impact factor: 6.543

6.  Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin-Induced Diabetic Rats.

Authors:  Bora Tastekin; Aykut Pelit; Sait Polat; Abdullah Tuli; Leman Sencar; Mustafa Muhlis Alparslan; Yusuf Kenan Daglioglu
Journal:  Evid Based Complement Alternat Med       Date:  2018-05-16       Impact factor: 2.629

7.  Effect of stilbene derivative on superoxide generation and enzyme release from human neutrophils in vitro.

Authors:  Tatiana Mačičková; Jana Pečivová; Juraj Harmatha; Klára Sviteková; Radomír Nosáľ
Journal:  Interdiscip Toxicol       Date:  2012-06

8.  The effects of pterostilbene on neutrophil activity in experimental model of arthritis.

Authors:  Tomas Perecko; Katarina Drabikova; Antonin Lojek; Milan Ciz; Silvester Ponist; Katarina Bauerova; Radomir Nosal; Juraj Harmatha; Viera Jancinova
Journal:  Biomed Res Int       Date:  2013-09-30       Impact factor: 3.411

Review 9.  Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer.

Authors:  Rong-Jane Chen; Hsiao-Che Kuo; Li-Hsin Cheng; Yu-Hsuan Lee; Wen-Tsan Chang; Bour-Jr Wang; Ying-Jan Wang; Hung-Chi Cheng
Journal:  Int J Mol Sci       Date:  2018-01-18       Impact factor: 5.923

Review 10.  Therapeutic Versatility of Resveratrol Derivatives.

Authors:  Waqas Nawaz; Zhongqin Zhou; Sa Deng; Xiaodong Ma; Xiaochi Ma; Chuangang Li; Xiaohong Shu
Journal:  Nutrients       Date:  2017-10-29       Impact factor: 5.717
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