Literature DB >> 1713202

In vitro neutralization of Chlamydia trachomatis by monovalent Fab antibody specific to the major outer membrane protein.

H Su1, H D Caldwell.   

Abstract

Monovalent Fab antibodies to serovar- and subspecies-specific epitopes of the major outer membrane protein (MOMP) of Chlamydia trachomatis neutralized infectivity for hamster kidney cells by preventing chlamydial attachment. These findings exclude the aggregation of chlamydiae as a mechanism of anti-MOMP neutralization and provide additional evidence in support of the MOMP as a chlamydial adhesin.

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Year:  1991        PMID： 1713202      PMCID： PMC258096          DOI： 10.1128/iai.59.8.2843-2845.1991

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  9 in total

1.  Chlamydia trachomatis-host cell interactions: role of the chlamydial major outer membrane protein as an adhesin.

Authors:  H Su; N G Watkins; Y X Zhang; H D Caldwell
Journal:  Infect Immun       Date:  1990-04       Impact factor: 3.441

2.  Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes.

Authors:  W Baehr; Y X Zhang; T Joseph; H Su; F E Nano; K D Everett; H D Caldwell
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

3.  Protective monoclonal antibodies to Chlamydia trachomatis serovar- and serogroup-specific major outer membrane protein determinants.

Authors:  Y X Zhang; S J Stewart; H D Caldwell
Journal:  Infect Immun       Date:  1989-02       Impact factor: 3.441

4.  Monoclonal antibody against a genus-specific antigen of Chlamydia species: location of the epitope on chlamydial lipopolysaccharide.

Authors:  H D Caldwell; P J Hitchcock
Journal:  Infect Immun       Date:  1984-05       Impact factor: 3.441

5.  Structural analysis of chlamydial major outer membrane proteins.

Authors:  H D Caldwell; R C Judd
Journal:  Infect Immun       Date:  1982-12       Impact factor: 3.441

6.  Protective monoclonal antibodies recognize epitopes located on the major outer membrane protein of Chlamydia trachomatis.

Authors:  Y X Zhang; S Stewart; T Joseph; H R Taylor; H D Caldwell
Journal:  J Immunol       Date:  1987-01-15       Impact factor: 5.422

7.  Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis.

Authors:  H D Caldwell; J Kromhout; J Schachter
Journal:  Infect Immun       Date:  1981-03       Impact factor: 3.441

8.  Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.

Authors:  P J Fraker; J C Speck
Journal:  Biochem Biophys Res Commun       Date:  1978-02-28       Impact factor: 3.575

9.  Enhancement of Chlamydia trachomatis infectious progeny by cultivation of HeLa 229 cells treated with DEAE-dextran and cycloheximide.

Authors:  S F Sabet; J Simmons; H D Caldwell
Journal:  J Clin Microbiol       Date:  1984-08       Impact factor: 5.948
  9 in total
  22 in total

1.  Characterization of outer membrane proteins in Chlamydia trachomatis LGV serovar L2.

Authors:  R J Tanzer; T P Hatch
Journal:  J Bacteriol       Date:  2001-04       Impact factor: 3.490

2.  A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection.

Authors:  Sandra G Morrison; Richard P Morrison
Journal:  J Immunol       Date:  2005-12-01       Impact factor: 5.422

3.  Analysis of the humoral immune response to Chlamydia outer membrane protein 2.

Authors:  P Mygind; G Christiansen; K Persson; S Birkelund
Journal:  Clin Diagn Lab Immunol       Date:  1998-05

4.  Antibody, but not B-cell-dependent antigen presentation, plays an essential role in preventing Chlamydia systemic dissemination in mice.

Authors:  Priyangi A Malaviarachchi; Miguel A B Mercado; Stephen J McSorley; Lin-Xi Li
Journal:  Eur J Immunol       Date:  2020-03-12       Impact factor: 5.532

5.  Sulfated polysaccharides and a synthetic sulfated polymer are potent inhibitors of Chlamydia trachomatis infectivity in vitro but lack protective efficacy in an in vivo murine model of chlamydial genital tract infection.

Authors:  H Su; H D Caldwell
Journal:  Infect Immun       Date:  1998-03       Impact factor: 3.441

6.  Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains.

Authors:  John H Carlson; Stephen F Porcella; Grant McClarty; Harlan D Caldwell
Journal:  Infect Immun       Date:  2005-10       Impact factor: 3.441

7.  Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice.

Authors:  H Su; K Feilzer; H D Caldwell; R P Morrison
Journal:  Infect Immun       Date:  1997-06       Impact factor: 3.441

8.  Protective efficacy of major outer membrane protein-specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection.

Authors:  T W Cotter; Q Meng; Z L Shen; Y X Zhang; H Su; H D Caldwell
Journal:  Infect Immun       Date:  1995-12       Impact factor: 3.441

9.  Recombinant Escherichia coli clones expressing Chlamydia trachomatis gene products attach to human endometrial epithelial cells.

Authors:  D H Schmiel; S T Knight; J E Raulston; J Choong; C H Davis; P B Wyrick
Journal:  Infect Immun       Date:  1991-11       Impact factor: 3.441

10.  Characterization of kinetics and target proteins for binding of human complement component C3 to the surface-exposed outer membrane of Chlamydia trachomatis serovar L2.

Authors:  R T Hall; T Strugnell; X Wu; D V Devine; H G Stiver
Journal:  Infect Immun       Date:  1993-05       Impact factor: 3.441
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