Mellar P Davis1. 1. The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, M76, Cleveland, OH 44195, USA. davism@ccf.org
Abstract
INTRODUCTION: Trazodone is a unique antidepressant, which blocks the postsynaptic serotonin (5-HT) receptors, 5-HT(2A) and 5-HT(2C), and weakly inhibits presynaptic 5-HT transporters. DISCUSSION: Trazodone is well-absorbed by the mouth and is metabolized by three cytochromes: CYP1A2, CYP2D6, and CYP3A4. Clinical benefits include reduced insomnia in those depressed and/or on antidepressants. Pain may be relieved by mechanisms similar to venlafaxine. Delirium unresponsive to neuroleptics has been reported to respond to trazodone. Drug interactions are a risk due to cytochrome metabolism. CONCLUSION: Trazodone has a unique pharmacology, which may be an advantage in palliating symptoms; however, little evidence is available through cohort or randomized trials to give guidance to its use.
INTRODUCTION:Trazodone is a unique antidepressant, which blocks the postsynaptic serotonin (5-HT) receptors, 5-HT(2A) and 5-HT(2C), and weakly inhibits presynaptic 5-HT transporters. DISCUSSION: Trazodone is well-absorbed by the mouth and is metabolized by three cytochromes: CYP1A2, CYP2D6, and CYP3A4. Clinical benefits include reduced insomnia in those depressed and/or on antidepressants. Pain may be relieved by mechanisms similar to venlafaxine. Delirium unresponsive to neuroleptics has been reported to respond to trazodone. Drug interactions are a risk due to cytochrome metabolism. CONCLUSION:Trazodone has a unique pharmacology, which may be an advantage in palliating symptoms; however, little evidence is available through cohort or randomized trials to give guidance to its use.
Authors: M Maes; H Westenberg; E Vandoolaeghe; P Demedts; A Wauters; H Neels; H Y Meltzer Journal: J Clin Psychopharmacol Date: 1997-10 Impact factor: 3.153
Authors: K Mihara; K Otani; M Ishida; N Yasui; A Suzuki; T Ohkubo; T Osanai; S Kaneko; K Sugawara Journal: Ther Drug Monit Date: 1997-02 Impact factor: 3.681
Authors: Luigi Grassi; Augusto Caraceni; Alex J Mitchell; Maria Giulia Nanni; Maria Alejandra Berardi; Rosangela Caruso; Michelle Riba Journal: Curr Psychiatry Rep Date: 2015-03 Impact factor: 5.285