Literature DB >> 17130820

4-Hydroxyproline metabolism and glyoxylate production: A target for substrate depletion in primary hyperoxaluria?

M B Coulter-Mackie1.   

Abstract

The primary hyperoxalurias are diseases of overproduction of oxalate. The immediate precursor of oxalate is glyoxylate. Metabolism of hydroxyproline, derived from collagen turnover or the diet, appears to be a major source of glyoxylate, and a potential target for a therapeutic strategy of substrate depletion.

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Year:  2006        PMID： 17130820     DOI： 10.1038/sj.ki.5001987

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  7 in total

1.  4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition.

Authors:  Travis J Riedel; John Knight; Michael S Murray; Dawn S Milliner; Ross P Holmes; W Todd Lowther
Journal:  Biochim Biophys Acta       Date:  2012-07-05

2.  Primary hyperoxaluria type III--a model for studying perturbations in glyoxylate metabolism.

Authors:  Ruth Belostotsky; James Jonathon Pitt; Yaacov Frishberg
Journal:  J Mol Med (Berl)       Date:  2012-06-24       Impact factor: 4.599

3.  Metabolism of [13C5]hydroxyproline in vitro and in vivo: implications for primary hyperoxaluria.

Authors:  Juquan Jiang; Lynnette C Johnson; John Knight; Michael F Callahan; Travis J Riedel; Ross P Holmes; W Todd Lowther
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2011-12-29       Impact factor: 4.052

4.  A conserved active site tyrosine residue of proline dehydrogenase helps enforce the preference for proline over hydroxyproline as the substrate.

Authors:  Elizabeth L Ostrander; John D Larson; Jonathan P Schuermann; John J Tanner
Journal:  Biochemistry       Date:  2009-02-10       Impact factor: 3.162

5.  Over-expression of a hydroxypyruvate reductase in Methylobacterium sp. MB200 enhances glyoxylate accumulation.

Authors:  Pei-Hong Shen; Bo Wu
Journal:  J Ind Microbiol Biotechnol       Date:  2007-07-25       Impact factor: 3.346

6.  Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.

Authors:  Travis J Riedel; Lynnette C Johnson; John Knight; Roy R Hantgan; Ross P Holmes; W Todd Lowther
Journal:  PLoS One       Date:  2011-10-06       Impact factor: 3.240

7.  Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans-4-hydroxy-L-proline.

Authors:  Alexandra N Bogner; Kyle M Stiers; Cole M McKay; Donald F Becker; John J Tanner
Journal:  Protein Sci       Date:  2021-06-04       Impact factor: 6.993
  7 in total

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