Literature DB >> 17130568

Genetic determinants of type 1 diabetes across populations.

Mohamed M Jahromi1, George S Eisenbarth.   

Abstract

T1D results from autoimmune-mediated destruction of the pancreatic beta cells, a process that is conditioned by multiple genes and environmental factors. The main genetic determinants map to the major histocompatibility complex (MHC), and in particular DR and DQ, although, genes outside the MHC contribute, including the insulin gene, PTPN22, and CTLA-4. There are remarkable differences in genetic susceptibility to T1D between populations. We believe this variation reflects differing frequencies of diabetes causative and protective alleles and haplotypes, and thus remains a major genetic influence linked to the MHC region not accounted for by DR and DQ alleles. In this article, we discuss global variations in genetic susceptibility to T1D in view of current genetic understanding.

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Year:  2006        PMID： 17130568     DOI： 10.1196/annals.1375.044

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  15 in total

1.  Brd2 disruption in mice causes severe obesity without Type 2 diabetes.

Authors:  Fangnian Wang; Hongsheng Liu; Wanda P Blanton; Anna Belkina; Nathan K Lebrasseur; Gerald V Denis
Journal:  Biochem J       Date:  2009-12-14       Impact factor: 3.857

2.  Study of factors influencing susceptibility and age at onset of type 1 diabetes: A review of data from Continental Italy and Sardinia.

Authors:  Fulvia Gloria-Bottini; Patrizia Saccucci; Gian Franco Meloni; Maria Luisa Manca-Bitti; Luca Coppeta; Anna Neri; Andrea Magrini; Bottini Egidio
Journal:  World J Diabetes       Date:  2014-08-15

3.  Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8.

Authors:  MyLinh Dang; Jennifer Rockell; Rebecca Wagner; Janet M Wenzlau; Liping Yu; John C Hutton; Peter A Gottlieb; Howard W Davidson
Journal:  J Immunol       Date:  2011-04-06       Impact factor: 5.422

4.  DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.

Authors:  Mihaela Stefan; Weijia Zhang; Erlinda Concepcion; Zhengzi Yi; Yaron Tomer
Journal:  J Autoimmun       Date:  2013-11-07       Impact factor: 7.094

5.  Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes.

Authors:  P G Bronson; P P Ramsay; G Thomson; L F Barcellos
Journal:  Diabetes Obes Metab       Date:  2009-02       Impact factor: 6.577

6.  Retro-inverso D-peptides as a novel targeted immunotherapy for Type 1 diabetes.

Authors:  Angela Lombardi; Erlinda Concepcion; Hanxi Hou; Hanane Arib; Mihaly Mezei; Roman Osman; Yaron Tomer
Journal:  J Autoimmun       Date:  2020-09-17       Impact factor: 7.094

7.  The CTLA4 -819 C/T and +49 A/G dimorphisms are associated with Type 1 diabetes in Egyptian children.

Authors:  Hatem Mohamed Saleh; Nestor Rohowsky; Michael Leski
Journal:  Indian J Hum Genet       Date:  2008-09

8.  Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes.

Authors:  Damien Bresson; Matthew Fradkin; Yulia Manenkova; Diane Rottembourg; Matthias von Herrath
Journal:  Mol Ther       Date:  2009-08-18       Impact factor: 11.454

Review 9.  Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms.

Authors:  Amanda Huber; Francesca Menconi; Sarah Corathers; Eric M Jacobson; Yaron Tomer
Journal:  Endocr Rev       Date:  2008-09-05       Impact factor: 19.871

Review 10.  DNA Methylation Patterning and the Regulation of Beta Cell Homeostasis.

Authors:  Nazia Parveen; Sangeeta Dhawan
Journal:  Front Endocrinol (Lausanne)       Date:  2021-05-07       Impact factor: 5.555
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