Literature DB >> 17128281

Opioid, cheating on its receptors, exacerbates pain.

Christophe Altier1, Gerald W Zamponi.   

Abstract

Opioids are commonly thought of as compounds that alleviate pain. A new study finds that elevated levels of the opioid dynorphin can unexpectedly activate bradykinin receptors, contributing to the maintenance of neuropathic pain.

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Year:  2006        PMID： 17128281     DOI： 10.1038/nn1206-1465b

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  9 in total

Review 1.  Endogenous opiates and behavior: 2006.

Authors:  Richard J Bodnar
Journal:  Peptides       Date:  2007-09-11       Impact factor: 3.750

2.  Dynorphin participates in interaction between depression and non-erosive reflux disease.

Authors:  Yi Wang; Bingduo Zhou; Shengquan Fang; Shengliang Zhu; Tingting Xu; Makan Dilikumaer; Guanwu Li
Journal:  Esophagus       Date:  2022-10-16       Impact factor: 3.671

3.  Cyclic non-opioid dynorphin A analogues for the bradykinin receptors.

Authors:  Yeon Sun Lee; Michael Remesic; Cyf Ramos-Colon; Sara M Hall; Alexander Kuzmin; David Rankin; Frank Porreca; Josephine Lai; Victor J Hruby
Journal:  Bioorg Med Chem Lett       Date:  2016-10-06       Impact factor: 2.823

Review 4.  Pronociceptive actions of dynorphin via bradykinin receptors.

Authors:  Josephine Lai; Miaw-chyi Luo; Qingmin Chen; Frank Porreca
Journal:  Neurosci Lett       Date:  2008-04-08       Impact factor: 3.046

5.  Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death.

Authors:  Thomas W Sherwood; Candice C Askwith
Journal:  J Neurosci       Date:  2009-11-11       Impact factor: 6.167

6.  Various modifications of the amphipathic dynorphin A pharmacophore for rat brain bradykinin receptors.

Authors:  Yeon Sun Lee; Robert Kupp; Michael V Remesic; Cyf Ramos-Colon; Sara M Hall; Christopher Chan; David Rankin; Josephine Lai; Frank Porreca; Victor J Hruby
Journal:  Chem Biol Drug Des       Date:  2016-06-06       Impact factor: 2.817

7.  Structure-activity relationships of non-opioid [des-Arg(7)]-dynorphin A analogues for bradykinin receptors.

Authors:  Yeon Sun Lee; David Rankin; Sara M Hall; Cyf Ramos-Colon; Jose Juan Ortiz; Robert Kupp; Frank Porreca; Josephine Lai; Victor J Hruby
Journal:  Bioorg Med Chem Lett       Date:  2014-09-19       Impact factor: 2.823

8.  Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord.

Authors:  Yeon Sun Lee; Dhanasekaran Muthu; Sara M Hall; Cyf Ramos-Colon; David Rankin; Jackie Hu; Alexander J Sandweiss; Milena De Felice; Jennifer Yanhua Xie; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Journal:  J Am Chem Soc       Date:  2014-04-29       Impact factor: 15.419

9.  Cerebellar developmental deficits underlie neurodegenerative disorder spinocerebellar ataxia type 23.

Authors:  Cleo J L M Smeets; Kai Yu Ma; Simon E Fisher; Dineke S Verbeek
Journal:  Brain Pathol       Date:  2020-11-02       Impact factor: 6.508
  9 in total

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