Literature DB >> 17128280

Triggering the brain's pathology sensor.

Helmut Kettenmann1.   

Abstract

Microglia, the brain's intrinsic immune cells, rapidly sense brain injury and help clear cellular debris. Haynes et al. now show that P2Y12 receptors are critical for activating microglia and directing them to the site of injury.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17128280     DOI： 10.1038/nn1206-1463

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  12 in total

Review 1.  Microglia: Housekeeper of the Central Nervous System.

Authors:  John Alimamy Kabba; Yazhou Xu; Handson Christian; Wenchen Ruan; Kitchen Chenai; Yun Xiang; Luyong Zhang; Juan M Saavedra; Tao Pang
Journal:  Cell Mol Neurobiol       Date:  2017-05-22       Impact factor: 5.046

2.  Differential modulation of angiogenesis by erythropoiesis-stimulating agents in a mouse model of ischaemic retinopathy.

Authors:  Carmel M McVicar; Liza M Colhoun; Jodie L Abrahams; Claire L Kitson; Ross Hamilton; Reinhold J Medina; Dash Durga; Tom A Gardiner; Pauline M Rudd; Alan W Stitt
Journal:  PLoS One       Date:  2010-07-29       Impact factor: 3.240

3.  Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition.

Authors:  Anna Lünemann; Jan D Lünemann; Susanne Roberts; Brady Messmer; Rosa Barreira da Silva; Cedric S Raine; Christian Münz
Journal:  J Immunol       Date:  2008-11-01       Impact factor: 5.422

4.  Isolation and ex vivo characterization of the immunophenotype and function of microglia/macrophage populations in normal dog retina.

Authors:  Sem Genini; William A Beltran; Veronika M Stein; Gustavo D Aguirre
Journal:  Adv Exp Med Biol       Date:  2014       Impact factor: 2.622

5.  Systemic LPS resulted in a transient hippocampus malfunction but a prolonged corpus callosum injury.

Authors:  Jie Zhang; Aiyuan Li; Zongbin Song
Journal:  BMC Anesthesiol       Date:  2017-08-14       Impact factor: 2.217

6.  Microglia activation mediated by toll-like receptor-4 impairs brain white matter tracts in rats.

Authors:  Xinglong Yang; Jing-Dong Zhang; Lian Duan; Huan-Gui Xiong; Yan-Ping Jiang; Hou-Cheng Liang
Journal:  J Biomed Res       Date:  2018-03-26

7.  Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.

Authors:  Amy L Brewster; Joaquin N Lugo; Vinit V Patil; Wai L Lee; Yan Qian; Fabiola Vanegas; Anne E Anderson
Journal:  PLoS One       Date:  2013-03-11       Impact factor: 3.240

8.  Two faces of chondroitin sulfate proteoglycan in spinal cord repair: a role in microglia/macrophage activation.

Authors:  Asya Rolls; Ravid Shechter; Anat London; Yifat Segev; Jasmin Jacob-Hirsch; Ninette Amariglio; Gidon Rechavi; Michal Schwartz
Journal:  PLoS Med       Date:  2008-08-19       Impact factor: 11.069

9.  DeltaRR vaccination protects from KA-induced seizures and neuronal loss through ICP10PK-mediated modulation of the neuronal-microglial axis.

Authors:  Jennifer M Laing; Laure Aurelian
Journal:  Genet Vaccines Ther       Date:  2008-01-07

10.  RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization.

Authors:  Mei Chen; Josephine V Glenn; Shilpa Dasari; Carmel McVicar; Michael Ward; Liza Colhoun; Michael Quinn; Angelika Bierhaus; Heping Xu; Alan W Stitt
Journal:  PLoS One       Date:  2014-02-26       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.