| Literature DB >> 17128271 |
Patricia A Maroney1, Yang Yu, Jesse Fisher, Timothy W Nilsen.
Abstract
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by binding the 3' untranslated regions of target mRNAs. We examined the subcellular distribution of three miRNAs in exponentially growing HeLa cells and found that the vast majority are associated with mRNAs in polysomes. Several lines of evidence indicate that most of these mRNAs, including a known miRNA-regulated target (KRAS mRNA), are actively being translated.Entities:
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Year: 2006 PMID： 17128271 DOI： 10.1038/nsmb1174
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369