Literature DB >> 17127354

Mitochondrial toxins and neurodegenerative diseases.

Antonio Ayala1, Jose L Venero, Josefina Cano, Alberto Machado.   

Abstract

The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in respiratory chain complex activities in mitochondria seems to be a causative factor. The aim of this review is to describe the most important toxins affecting the mitochondrial function, which could be involved in the incidence of some of these diseases: MPTP, rotenone and 3-nitropropionic (3-NPA).

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Year:  2007        PMID： 17127354     DOI： 10.2741/2119

Source DB:  PubMed          Journal:  Front Biosci        ISSN： 1093-4715


  17 in total

1.  Acute exposure to the mitochondrial complex I toxin rotenone impairs synaptic long-term potentiation in rat hippocampal slices.

Authors:  Ryoichi Kimura; Lu-Yao Ma; Chen Wu; Dharshaun Turner; Jian-Xin Shen; Kevin Ellsworth; Makoto Wakui; Marwan Maalouf; Jie Wu
Journal:  CNS Neurosci Ther       Date:  2012-05-22       Impact factor: 5.243

2.  Semisynthetic studies identify mitochondria poisons from botanical dietary supplements--geranyloxycoumarins from Aegle marmelos.

Authors:  Jun Li; Fakhri Mahdi; Lin Du; Mika B Jekabsons; Yu-Dong Zhou; Dale G Nagle
Journal:  Bioorg Med Chem       Date:  2013-02-04       Impact factor: 3.641

3.  Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy.

Authors:  Vinay Choubey; Dzhamilja Safiulina; Annika Vaarmann; Michal Cagalinec; Przemyslaw Wareski; Malle Kuum; Alexander Zharkovsky; Allen Kaasik
Journal:  J Biol Chem       Date:  2011-01-20       Impact factor: 5.157

4.  Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD.

Authors:  Sayak K Mitter; Chunjuan Song; Xiaoping Qi; Haoyu Mao; Haripriya Rao; Debra Akin; Alfred Lewin; Maria Grant; William Dunn; Jindong Ding; Catherine Bowes Rickman; Michael Boulton
Journal:  Autophagy       Date:  2014       Impact factor: 16.016

5.  Complex I dysfunction redirects cellular and mitochondrial metabolism in Arabidopsis.

Authors:  Marie Garmier; Adam J Carroll; Etienne Delannoy; Corinne Vallet; David A Day; Ian D Small; A Harvey Millar
Journal:  Plant Physiol       Date:  2008-09-10       Impact factor: 8.340

6.  Remodeled respiration in ndufs4 with low phosphorylation efficiency suppresses Arabidopsis germination and growth and alters control of metabolism at night.

Authors:  Etienne H Meyer; Tiago Tomaz; Adam J Carroll; Gonzalo Estavillo; Etienne Delannoy; Sandra K Tanz; Ian D Small; Barry J Pogson; A Harvey Millar
Journal:  Plant Physiol       Date:  2009-08-12       Impact factor: 8.340

7.  Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.

Authors:  Linhui Julie Su; Pavan K Auluck; Tiago Fleming Outeiro; Esti Yeger-Lotem; Joshua A Kritzer; Daniel F Tardiff; Katherine E Strathearn; Fang Liu; Songsong Cao; Shusei Hamamichi; Kathryn J Hill; Kim A Caldwell; George W Bell; Ernest Fraenkel; Antony A Cooper; Guy A Caldwell; J Michael McCaffery; Jean-Christophe Rochet; Susan Lindquist
Journal:  Dis Model Mech       Date:  2009-12-28       Impact factor: 5.758

8.  Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors.

Authors:  Do Young Kim; Johana Vallejo; Jong M Rho
Journal:  J Neurochem       Date:  2010-04-02       Impact factor: 5.372

Review 9.  Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders.

Authors:  Sarah van Veen; Danny M Sørensen; Tine Holemans; Henrik W Holen; Michael G Palmgren; Peter Vangheluwe
Journal:  Front Mol Neurosci       Date:  2014-05-27       Impact factor: 5.639

10.  The Pael-R gene does not mediate the changes in rotenone-induced Parkinson's disease model cells.

Authors:  Ting Zou; Xiangqi Tang; Zhiling Huang; Niangui Xu; Zhiping Hu
Journal:  Neural Regen Res       Date:  2014-02-15       Impact factor: 5.135
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