| Literature DB >> 17127068 |
Yu-Guo Fang1, Ji Zhang, Shan-Yong Chen, Ning Jiang, Hong-Hui Lin, Yu Zhang, Xiao-Qi Yu.
Abstract
A series of multinuclear macrocyclic polyamine metal (Zn(2+), Cu(2+), Co(2+)) complexes containing chiral dipeptide linkage were synthesized and used as artificial nuclease enzyme model. The interaction between the complexes and plasmid DNA (pUC19) was studied, and the results revealed that these complexes could act as powerful catalysts for the cleavage of plasmid DNA under physiological conditions.Entities:
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Year: 2006 PMID： 17127068 DOI： 10.1016/j.bmc.2006.10.057
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641