Literature DB >> 17127062

1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors.

Mark J Mulvihill1, Qun-Sheng Ji, Doug Werner, Patricia Beck, Cara Cesario, Andrew Cooke, Matthew Cox, Andrew Crew, Hanqing Dong, Lixin Feng, K W Foreman, Gilda Mak, Anthony Nigro, Matthew O'Connor, Lydia Saroglou, Kathryn M Stolz, Izabela Sujka, Brian Volk, Qinghua Weng, Robin Wilkes.   

Abstract

A series of novel 8-amino-1,3-disubstituted-imidazo[1,5-a]pyrazines was designed and synthesized as IGF-IR inhibitors.

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Year:  2006        PMID： 17127062     DOI： 10.1016/j.bmcl.2006.11.016

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?

Authors:  Terry J Smith
Journal:  Pharmacol Rev       Date:  2010-04-14       Impact factor: 25.468

Review 2.  Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.

Authors:  Rongshi Li; Alan Pourpak; Stephan W Morris
Journal:  J Med Chem       Date:  2009-08-27       Impact factor: 7.446

3.  Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.

Authors:  Rama Subba Rao Vidadala; Kayode K Ojo; Steven M Johnson; Zhongsheng Zhang; Stephen E Leonard; Arinjay Mitra; Ryan Choi; Molly C Reid; Katelyn R Keyloun; Anna M W Fox; Mark Kennedy; Tiffany Silver-Brace; Jen C C Hume; Stefan Kappe; Christophe L M J Verlinde; Erkang Fan; Ethan A Merritt; Wesley C Van Voorhis; Dustin J Maly
Journal:  Eur J Med Chem       Date:  2014-01-11       Impact factor: 6.514

4.  Virtual screening of specific insulin-like growth factor 1 receptor (IGF1R) inhibitors from the National Cancer Institute (NCI) molecular database.

Authors:  Cong Fan; Yan-Xin Huang; Yong-Li Bao; Lu-Guo Sun; Yin Wu; Chun-Lei Yu; Yu Zhang; Zhen-Bo Song; Li-Hua Zheng; Ying Sun; Guan-Nan Wang; Yu-Xin Li
Journal:  Int J Mol Sci       Date:  2012-12-14       Impact factor: 5.923

5.  Receptor guided 3D-QSAR: a useful approach for designing of IGF-1R inhibitors.

Authors:  M Muddassar; F A Pasha; H W Chung; K H Yoo; C H Oh; S J Cho
Journal:  J Biomed Biotechnol       Date:  2008
  5 in total

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