| Literature DB >> 17127055 |
Colin P Leslie1, Romano Di Fabio, Francesca Bonetti, Manuela Borriello, Simone Braggio, Giovanna Dal Forno, Daniele Donati, Alessandro Falchi, Damiano Ghirlanda, Riccardo Giovannini, Francesca Pavone, Angelo Pecunioso, Giorgio Pentassuglia, Domenica A Pizzi, Giovanna Rumboldt, Luigi Stasi.
Abstract
The synthesis of a series of carbazole derivatives and their SAR at the NPY Y1 receptor is described. Modulation of physicochemical properties by appropriate decoration led to the identification of a high-affinity NPY Y1 antagonist that shows high brain penetration and modest oral bioavailability.Entities:
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Year: 2006 PMID： 17127055 DOI： 10.1016/j.bmcl.2006.11.034
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823