Literature DB >> 1712659

Mechanism of modulation of GABA-activated current by internal calcium in rat central neurons.

S M Marchenko1.   

Abstract

GABA-activated currents in Purkinje cells isolated from rat cerebellum were investigated. Increase of intracellular Ca2+ in the physiological range of concentrations caused a decrease in GABA-activated chloride currents. This effect resulted from a decrease of both the maximal values of GABA-activated currents and possibly from the affinity of GABAA receptors. Therefore, the mechanism of Ca2+ effect on GABAA receptors in central rat neurons differs from that in bullfrog sensory neurons.

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Year:  1991        PMID： 1712659     DOI： 10.1016/0006-8993(91)91502-r

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  Impaired motor coordination and Purkinje cell excitability in mice lacking calretinin.

Authors:  S N Schiffmann; G Cheron; A Lohof; P d'Alcantara; M Meyer; M Parmentier; S Schurmans
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

2.  Studies of long-term potentiation and depression of inhibitory transmission by mathematical modeling of post-synaptic processes.

Authors:  G B Murzina; I G Sil'kis
Journal:  Neurosci Behav Physiol       Date:  1998 Mar-Apr

3.  The effect of intracellular Ca2+ on GABA-activated currents in cerebellar granule cells in culture.

Authors:  M Martina; G Kilić; E Cherubini
Journal:  J Membr Biol       Date:  1994-11       Impact factor: 1.843

Review 4.  [Refractory status epilepticus: diagnosis, therapy, course, and prognosis].

Authors:  F Bösebeck; G Möddel; K Anneken; M Fischera; S Evers; E B Ringelstein; C Kellinghaus
Journal:  Nervenarzt       Date:  2006-10       Impact factor: 1.214

5.  Inhibition of GABAA synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus.

Authors:  T Tanaka; H Saito; N Matsuki
Journal:  J Neurosci       Date:  1997-05-01       Impact factor: 6.167

Review 6.  Activation by GABAb, reduction of the intracellular concentration of Ca++, and inhibition of protein kinases are possible mechanisms of the long-term posttetanic modification of the efficiency of inhibitory transmission in the new cortex.

Authors:  I G Sil'kis
Journal:  Neurosci Behav Physiol       Date:  1996 Jan-Feb

7.  Enhanced GABA(A) receptor-mediated activity following activation of NMDA receptors in Cajal-Retzius cells in the developing mouse neocortex.

Authors:  Chun-Hung Chan; Hermes H Yeh
Journal:  J Physiol       Date:  2003-05-02       Impact factor: 5.182

8.  Modulation of Ca²⁺ signals by epigallocatechin-3-gallate(EGCG) in cultured rat hippocampal neurons.

Authors:  Jiang-Hua Wang; Jin Cheng; Cai-Rong Li; Mao Ye; Zhe Ma; Fei Cai
Journal:  Int J Mol Sci       Date:  2011-01-20       Impact factor: 5.923
  8 in total

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