| Literature DB >> 17126511 |
Hui-Ying Lim1, Rolf Bodmer, Laurent Perrin.
Abstract
Drosophila continues to be a model system of choice to study the genetics of aging. It has a short lifespan and small genome size, but nevertheless contains a complex organ and endocrine system that allows studying the role of conserved signal transduction pathways with sophisticated genetic tools. Oxidative stress and metabolic changes along with intersecting signaling systems Insulin Receptor (InR), Target of Rapamycin (TOR) and Jun N-terminal Kinase (JNK) have emerged as some of the major players in aging. Sleep and organ-specific aging has also been the subject of recent progress in understanding aging.Entities:
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Year: 2006 PMID： 17126511 PMCID： PMC1855203 DOI： 10.1016/j.exger.2006.10.013
Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032